| Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. | |
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MedLine Citation:
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PMID: 20041738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aged mice treated peripherally with lipopolysaccharide (LPS) show an exaggerated neuroinflammatory response and cognitive deficits compared to adults. Considerable evidence suggests resveratrol, a polyphenol found in red grapes, has potent antiinflammatory effects in the periphery, but its effects on the central inflammatory response and cognitive behavior are unknown. Therefore, the current study investigated if resveratrol dietary supplementation would inhibit neuroinflammation as well as behavioral and cognitive deficits in aged mice given LPS to mimic a peripheral infection. In initial studies, adult (3-6 months) and aged (22-24 months) mice were provided control or resveratrol-supplemented diet for 4 weeks and then injected intraperitoneally (i.p.) with saline or LPS, and locomotor activity and spatial working memory were assessed. As anticipated, deficits in locomotor activity and spatial working memory indicated aged mice are more sensitive to LPS compared to adults. More importantly, the LPS-induced deficits in aged animals were mitigated by dietary supplementation of resveratrol. In addition, resveratrol consumption reduced LPS-induced interleukin-1beta (IL-1beta) in plasma and the IL-1beta mRNA in the hippocampus of aged mice. Finally, pretreatment of BV-2 microglial cells with resveratrol potently inhibited LPS-induced IL-1beta production. These data show that aged mice are more sensitive than adult mice to both the inflammatory and cognitive effects of peripheral immune stimulation and suggest that resveratrol may be useful for attenuating acute cognitive disorders in elderly individuals with an infection. |
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Authors:
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Jayne Abraham; Rodney W Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rejuvenation research Volume: 12 ISSN: 1557-8577 ISO Abbreviation: Rejuvenation Res Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-31 Completed Date: 2010-03-03 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 445-53 Citation Subset: IM |
Affiliation:
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Division of Nutritional Sciences, University of Illinois, Urbana, Illinois 61801, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects,
pathology* Animals Behavior, Animal / drug effects Dietary Supplements* Gene Expression Regulation / drug effects Hippocampus / drug effects, metabolism Inflammation / pathology* Interleukin-1beta / genetics, secretion Lipopolysaccharides / administration & dosage, pharmacology Male Maze Learning / drug effects Memory, Short-Term / drug effects* Mice Mice, Inbred BALB C Microglia / drug effects, secretion Nervous System / drug effects*, pathology* Stilbenes / administration & dosage, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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5T32 DK59802/DK/NIDDK NIH HHS; AG16710/AG/NIA NIH HHS; MH069148/MH/NIMH NIH HHS; R01 AG016710-09/AG/NIA NIH HHS; R01 MH069148-05/MH/NIMH NIH HHS; T32 DK059802-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Lipopolysaccharides; 0/Stilbenes; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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