| Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. | |
| | |
MedLine Citation:
|
PMID: 12473409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To fully apply already published procedures for the safety evaluation of fragrance ingredients, it is necessary to estimate exposure through different routes and leading to different potential endpoints. Worst-case scenario calculations indicate that deposition on the surface of the skin following use of cosmetics represents the major route of exposure to fragrance ingredients when conservative estimates for evaporation, rinsing, and other forms of product removal are employed. Hydroalcoholic perfumes and colognes deliver the highest dose after single product use. Surveys of formulas used in this type of product allow the calculation of average maximum or upper 97.5th percentile concentration of the ingredient in formulas. With this type of exaggeration, the use of estimates of "typical" cosmetic use can be maximized to take account of excessive consumption patterns for both short-term and long-term exposure estimates. In the latter case, multiple product use must be considered. Short-term exposure (single product doses) of an ingredient found at an average maximum use level of P% in fragrances is taken to be 0.2 x P% or 3P microg/cm(2). Using upper 97.5th percentile concentrations (P(97.5)) of individual ingredients in fragrances, the long-term exposure is taken to be P(97.5) x 2,547 microg/kg body wt/day. The estimates of long-term exposure incorporate a number of highly conservative assumptions (e.g., over a long period, every product used will contain a fragrance with this ingredient at this high (P(97.5)) level). |
| | |
Authors:
|
Peter A Cadby; William R Troy; Matthias G H Vey |
Related Documents
:
|
3462019 - Lung function and bronchial hyperreactivity following exposure to four different temper... 11386719 - Cholinergic and behavioral neurotoxicity of carbaryl and cadmium to larval rainbow trou... 3895719 - Radiation effects on livestock: physiological effects, dose response. 9799949 - Methods for health risk assessment of chemicals: are they relevant for alcohol? 2332399 - The establishment and persistence of food preferences in lambs exposed to selected foods. 19572769 - Growth and development of tadpoles (xenopus laevis) exposed to selective serotonin reup... 23041489 - The food retail environment in school neighborhoods and its relation to lunchtime eatin... 23275869 - Bacteriophage cocktail significantly reduces escherichia coli o157: h7 contamination of... 18845469 - Healthy food choices and physical activity opportunities in two contrasting alabama cit... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Regulatory toxicology and pharmacology : RTP Volume: 36 ISSN: 0273-2300 ISO Abbreviation: Regul. Toxicol. Pharmacol. Publication Date: 2002 Dec |
Date Detail:
|
Created Date: 2002-12-10 Completed Date: 2003-05-06 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8214983 Medline TA: Regul Toxicol Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 246-52 Citation Subset: IM |
Affiliation:
|
International Fragrance Association, 49 Square Marie-Louise, B-1000 Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Dermatitis, Phototoxic Dose-Response Relationship, Drug Environmental Exposure* Humans Models, Theoretical* Perfume / adverse effects*, chemistry Risk Assessment Safety |
| Chemical | |
Reg. No./Substance:
|
0/Perfume |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physiologically based pharmacokinetic (PBPK) models for nasal tissue dosimetry of organic esters: as...
Next Document: Prediction of local irritant effects after repeated dermal and respiratory exposure to chemicals.