Document Detail


Consumer exposure to fragrance ingredients: providing estimates for safety evaluation.
MedLine Citation:
PMID:  12473409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To fully apply already published procedures for the safety evaluation of fragrance ingredients, it is necessary to estimate exposure through different routes and leading to different potential endpoints. Worst-case scenario calculations indicate that deposition on the surface of the skin following use of cosmetics represents the major route of exposure to fragrance ingredients when conservative estimates for evaporation, rinsing, and other forms of product removal are employed. Hydroalcoholic perfumes and colognes deliver the highest dose after single product use. Surveys of formulas used in this type of product allow the calculation of average maximum or upper 97.5th percentile concentration of the ingredient in formulas. With this type of exaggeration, the use of estimates of "typical" cosmetic use can be maximized to take account of excessive consumption patterns for both short-term and long-term exposure estimates. In the latter case, multiple product use must be considered. Short-term exposure (single product doses) of an ingredient found at an average maximum use level of P% in fragrances is taken to be 0.2 x P% or 3P microg/cm(2). Using upper 97.5th percentile concentrations (P(97.5)) of individual ingredients in fragrances, the long-term exposure is taken to be P(97.5) x 2,547 microg/kg body wt/day. The estimates of long-term exposure incorporate a number of highly conservative assumptions (e.g., over a long period, every product used will contain a fragrance with this ingredient at this high (P(97.5)) level).
Authors:
Peter A Cadby; William R Troy; Matthias G H Vey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  36     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-10     Completed Date:  2003-05-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM    
Affiliation:
International Fragrance Association, 49 Square Marie-Louise, B-1000 Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Dermatitis, Phototoxic
Dose-Response Relationship, Drug
Environmental Exposure*
Humans
Models, Theoretical*
Perfume / adverse effects*,  chemistry
Risk Assessment
Safety
Chemical
Reg. No./Substance:
0/Perfume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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