Document Detail


Consultative hematology: the pregnant patient pregnancy loss.
MedLine Citation:
PMID:  21239788     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The presence of antiphospholipid antibodies has been associated with an increased risk of recurrent pregnancy loss, and there is evidence to suggest that antithrombotic therapy improves the likelihood of a successful outcome in affected women. Recent studies suggest an association between hereditary thrombophilia and pregnancy loss, although a causal role remains controversial. Although the available data are limited and flawed, there is increasing use of antithrombotic therapy in thrombophilic women with a history of pregnancy failure. Given the absence of proven effective therapy in women with unexplained recurrent loss, there is also growing pressure to intervene with antithrombotics in women with no known underlying thrombophilia. This article reviews the evidence for an association between thrombophilia and recurrent pregnancy loss and the data regarding the use of antithrombotic therapy for prevention of loss-an area that remains particularly challenging because of the paucity of good quality data upon which to base clinical decisions.
Authors:
Shannon M Bates
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program     Volume:  2010     ISSN:  1520-4383     ISO Abbreviation:  Hematology Am Soc Hematol Educ Program     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890099     Medline TA:  Hematology Am Soc Hematol Educ Program     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
Affiliation:
1Department of Medicine, McMaster University & Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
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