Document Detail


Construction of a tunable metallohydrolase center on an invertible molecular pocket.
MedLine Citation:
PMID:  21989979     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A trimer of cholic acid made by linking three cholic acid molecules with pentaerythritol via click chemistry serves as the center of an artificial metallohydrolase after the complexation of the triazole groups with a Zn(2+) ion. The invertible amphiphilic cavity can respond to the change in polarity of the solvent media and efficiently modulate the catalytic activity of the artificial enzyme.
Authors:
Zhiming Zhang; Junqiu Liu; Quan Luo; Jiawei Zhang; Jiayun Xu; X X Zhu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-11
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China. junqiuliu@jlu.edu.cn.
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