| Construction of substituted cyclohexanones by reductive cyclization of 7-oxo-2,8-alkadienyl esters. | |
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MedLine Citation:
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PMID: 11772095 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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[reaction: see text] Cyclization of 7-oxo-2,8-alkadienyl esters upon reaction with triphenylphosphinecopper hydride hexamer stereoselectively yields substituted cyclohexanones having a cis relationship of carbon side chains at C2 and C3. This cyclohexanone construction is particularly useful for preparing 4-alkoxy- or 4-siloxy-2,3-disubstituted cyclohexanones, in which instance stereoselection is > or = 20:1. |
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Authors:
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Theodore M Kamenecka; Larry E Overman; Sylvie K Ly Sakata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Organic letters Volume: 4 ISSN: 1523-7060 ISO Abbreviation: Org. Lett. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-04 Completed Date: 2002-02-19 Revised Date: 2003-10-31 |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 79-82 Citation Subset: - |
Affiliation:
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Department of Chemistry, University of California, Irvine, 516 Rowland Hall, Irvine, California 92697-2025, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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