Document Detail


Construction of pigmented skin equivalent and its application to the study of congenital disorders of pigmentation.
MedLine Citation:
PMID:  16298805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have constructed a pigmented skin equivalent and used it to study the hyperpigmentation seen in café-au-lait macules to elucidate whether the pigmented skin equivalent could be used as a model of congenital hyperpigmentary disorders. When we used fibroblasts derived from café-au-lait macules of neurofibromatosis type 1, the amount of pigment was significantly greater than in models using cells derived from normal skin. Quantities of pigment were not seen when keratinocytes derived from solitary café-au-lait macules were used, a possible reason being that keratinocytes on the skin equivalent are in a proliferating condition and are not well-differentiated enough to act on other cells. Our results suggested that our pigmented skin equivalent is useful for the study of congenital hyperpigmentary disorders, although insufficient differentiation of keratinocytes might be a disadvantage.
Authors:
Mutsumi Okazaki; Yasutoshi Suzuki; Kotaro Yoshimura; Kiyonori Harii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi     Volume:  39     ISSN:  0284-4311     ISO Abbreviation:  Scand J Plast Reconstr Surg Hand Surg     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707869     Medline TA:  Scand J Plast Reconstr Surg Hand Surg     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  339-43     Citation Subset:  IM    
Affiliation:
Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Japan. okazaki-m@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Cafe-au-Lait Spots / pathology*
Cells, Cultured*
Collagen / metabolism
Fibroblasts / metabolism
Humans
Keratinocytes / metabolism
Melanocytes / metabolism*
Models, Biological
Neurofibromatosis 1 / pathology*
Skin / cytology*
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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