| Construction of an exposure chamber for animals and its use for inhalation exposure to welding fumes and gases. | |
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MedLine Citation:
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PMID: 10943081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An inhalation exposure system, consisting of an inhalation chamber and an generating and feeding device for welding fumes and gases with a welding robot, was constructed and examined for its application to experimental toxicology for ventilatory responses of conscious rats to welding fumes and gases. The exposure system allowed an inhalation of fresh welding fumes and gases, and could supply airflow containing stable concentrations of fumes and ozone even the levels exceeding those corresponding occupational exposure limit values were supplied into the exposure chamber. The air temperature in the chamber was kept constant under rat's physiological conditions. Rats were exposed to fresh welding fumes and gases and examined for their ventilatory responses with a body plethysmograph in the chamber. A transient increase in breathing frequency with a concomitant decrease in the tidal volume was observed within several minutes immediately after the start of welding operation. The rapid, shallow breathing response disappears after repeated exposures, indicating rapid adaptation of this ventilatory response to inhalation of welding fumes and gases. |
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Authors:
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H Saito; J Ojima; H Takahashi; T Iwasaki; N Hisanaga; H Arito |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Industrial health Volume: 38 ISSN: 0019-8366 ISO Abbreviation: Ind Health Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-09-19 Completed Date: 2000-09-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985065R Medline TA: Ind Health Country: JAPAN |
Other Details:
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Languages: eng Pagination: 323-6 Citation Subset: IM |
Affiliation:
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National Institute of Industrial Health, Kawasaki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Carbon Monoxide / administration & dosage, adverse effects* Gases Inhalation Exposure Male Oxidants, Photochemical / administration & dosage, adverse effects* Ozone / administration & dosage, adverse effects* Rats Rats, Wistar Respiration Tidal Volume Welding* |
| Chemical | |
Reg. No./Substance:
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0/Gases; 0/Oxidants, Photochemical; 10028-15-6/Ozone; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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