Document Detail


Construction and analysis of single nucleotide polymorphism-single nucleotide polymorphism interaction networks.
MedLine Citation:
PMID:  24067417     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The study of gene regulatory network and protein-protein interaction network is believed to be fundamental to the understanding of molecular processes and functions in systems biology. In this study, the authors are interested in single nucleotide polymorphism (SNP) level and construct SNP-SNP interaction network to understand genetic characters and pathogenetic mechanisms of complex diseases. The authors employ existing methods to mine, model and evaluate a SNP sub-network from SNP-SNP interactions. In the study, the authors employ the two SNP datasets: Parkinson disease and coronary artery disease to demonstrate the procedure of construction and analysis of SNP-SNP interaction networks. Experimental results are reported to demonstrate the procedure of construction and analysis of such SNP-SNP interaction networks can recover some existing biological results and related disease genes.
Authors:
Yang Liu; Xutao Li; Zhiping Liu; Luonan Chen; Michael K Ng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  IET systems biology     Volume:  7     ISSN:  1751-8849     ISO Abbreviation:  IET Syst Biol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101301198     Medline TA:  IET Syst Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-81     Citation Subset:  IM    
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