Document Detail


Construction of a Well-Defined Multifunctional Dendrimer for Theranostics.
MedLine Citation:
PMID:  21291239     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A dendrimer-based building block for theranostics was designed. The multifunctional dendrimer is polyamide-based and contains nine azide termini, nine amine termini, and fifty-four terminal acid groups. Orthogonal functionalization of the multifunctional dendrimer with a near-infrared (NIR) cyanine dye afforded the final dendrimer that shows fluorescence in the NIR region and no toxicity toward T98G human cells. The synthetic strategy described here might be promising for fabricating the next generation of materials for theranostics.
Authors:
Cátia Ornelas; Ryan Pennell; Leonard F Liebes; Marcus Weck
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-3
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Molecular Design Institute and Department of Chemistry, New York University, 31 Washington Place, New York, New York 10003, United States, and Cancer Institute, New York University School of Medicine, Tisch Hospital, 550 First Avenue, New York, New York 10016, United States.
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