| Construction of relational topographies from the quantitative measurements of functional deep brain stimulation using a 'roving window' interpolation algorithm. | |
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MedLine Citation:
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PMID: 19940545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The delivery of stimulus by a deep brain stimulation (DBS) contact electrode at a particular location may lead to a quantifiable physiologic effect, both intraoperatively and postoperatively. Consequently, measured data values can be attributed to discrete scattered points in neuroanatomic space, allowing for interpolative techniques to generate a topographic map of spatial patterns. Ultimately, by relating the topographies of various intraoperative measurements to the postoperative counterparts and neuroanatomic atlases, outcome-guided adjustments to electrode position can be pursued intraoperatively. In this study, 52 Parkinson's disease patients were tested with a postoperative trial of stimulation and thresholds were recorded for motor adverse effects. A 'roving window' interpolation algorithm was adapted to generate a topographic map of voltage threshold along selected axial, coronal and sagittal planes. By developing these relational topographies for a variety of intraoperative and postoperative effects, a multivariable approach towards DBS optimization emerges. |
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Authors:
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Mahesh B Shenai; Harrison Walker; Stephanie Guthrie; Ray Watts; Barton L Guthrie |
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Publication Detail:
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Type: Journal Article Date: 2009-11-20 |
Journal Detail:
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Title: Stereotactic and functional neurosurgery Volume: 88 ISSN: 1423-0372 ISO Abbreviation: Stereotact Funct Neurosurg Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902881 Medline TA: Stereotact Funct Neurosurg Country: Switzerland |
Other Details:
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Languages: eng Pagination: 16-23 Citation Subset: IM |
Copyright Information:
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2009 S. Karger AG, Basel. |
Affiliation:
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Division of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL 35294-3410, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Algorithms Brain Mapping / methods* Deep Brain Stimulation / adverse effects, methods* Electrodes, Implanted Female Humans Male Middle Aged Models, Neurological Parkinson Disease / physiopathology*, surgery Subthalamic Nucleus / physiopathology*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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