Document Detail

Construction of Chiral Tertiary Alcohol Stereocenters via the [2, 3] Meisenheimer Rearrangement: Enantioselective Synthesis of the Side Chain Acids of Homoharringtonine and Harringtonine.
MedLine Citation:
PMID:  23214949     Owner:  NLM     Status:  Publisher    
For the first time the [2,3]-Meisenheimer rearrangement has been developed into a general strategy for the construction of chiral tertiary alcohols. The effectiveness and practicality of this methodology are illustrated by the successful synthesis of (R)-20 and (R)-30, the side chain acid of homoharringtonine and harringtonine respectively.
Hua Yang; Moran Sun; Shuguang Zhao; Ming Zhu; Yangla Xie; Changling Niu; Chunlin Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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