| Construction of an All-Carbon Quaternary Stereocenter by the Peptide-Catalyzed Asymmetric Michael Addition of Nitromethane to β-Disubstituted α,β-Unsaturated Aldehydes. | |
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MedLine Citation:
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PMID: 23143984 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pepping up Michael: An asymmetric Michael addition of nitromethane to β-disubstituted α,β-unsaturated aldehydes was realized by a resin-supported peptide catalyst. Whereas the use of a low-molecular-weight catalyst resulted in poor yields, the peptide effectively promoted the reaction in aqueous media with high enantioselectivity. |
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Authors:
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Kengo Akagawa; Kazuaki Kudo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 (Japan). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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