Document Detail

Constructing Metabolic Association Networks Using High-dimensional Mass Spectrometry Data.
MedLine Citation:
PMID:  25414536     Owner:  NLM     Status:  Publisher    
The goal of metabolic association networks is to identify topology of a metabolic network for a better understanding of molecular mechanisms. An accurate metabolic association network enables investigation of the functional behavior of metabolites in a cell or tissue. Gaussian Graphical model (GGM)-based methods have been widely used in genomics to infer biological networks. However, the performance of various GGM-based methods for the construction of metabolic association networks remains unknown in metabolomics. The performance of principle component regression (PCR), independent component regression (ICR), shrinkage covariance estimate (SCE), partial least squares regression (PLSR), and extrinsic similarity (ES) methods in constructing metabolic association networks was compared by estimating partial correlation coefficient matrices when the number of variables is larger than the sample size. To do this, the sample size and the network density (complexity) were considered as variables for network construction. Simulation studies show that PCR and ICR are more stable to the sample size and the network density than SCE and PLSR in terms of F1 scores. These methods were further applied to analysis of experimental metabolomics data acquired from metabolite extract of mouse liver. For the simulated data, the proposed methods PCR and ICR outperform other methods when the network density is large, while PLSR and SCE perform better when the network density is small. As for experimental metabolomics data, PCR and ICR discover more significant edges and perform better than PLSR and SCE when the discovered edges are evaluated using KEGG pathway. These results suggest that the metabolic network is more complex than the genomic network and therefore, PCR and ICR have the advantage over PLSR and SCE in constructing the metabolic association networks.
Imhoi Koo; Xiaoli Wei; Xue Shi; Zhanxiang Zhou; Seongho Kim; Xiang Zhang
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Publication Detail:
Journal Detail:
Title:  Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society     Volume:  138     ISSN:  0169-7439     ISO Abbreviation:  Chemometr Intell Lab Syst     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  8711218     Medline TA:  Chemometr Intell Lab Syst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  193-202     Citation Subset:  -    
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