| Construct validity and frequency of euphoria sclerotica in multiple sclerosis. | |
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MedLine Citation:
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PMID: 15377743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the Neuropsychiatric Inventory (NPI), we studied euphoria and other behavioral changes in 75 consecutive, unselected multiple sclerosis (MS) patients and 25 healthy controls. We also assessed disease duration, clinical course, physical disability, personality, depression, insight, cognition, and caregiver distress. Factor analysis identified a cluster of symptoms--labeled euphoria/disinhibition--similar to the euphoria sclerotica syndrome originally described by Charcot and others. The euphoria/disinhibition factor score was elevated in 9% of patients and associated with secondary-progressive course, low agreeableness, poor insight, impaired cognition, and high caregiver distress. Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates. |
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Authors:
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Inna Fishman; Ralph H B Benedict; Rohit Bakshi; Roger Priore; Bianca Weinstock-Guttman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of neuropsychiatry and clinical neurosciences Volume: 16 ISSN: 0895-0172 ISO Abbreviation: J Neuropsychiatry Clin Neurosci Publication Date: 2004 |
Date Detail:
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Created Date: 2004-09-20 Completed Date: 2004-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8911344 Medline TA: J Neuropsychiatry Clin Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 350-6 Citation Subset: IM |
Affiliation:
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State University of New York (SUNY) Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Behavioral Symptoms / etiology* Euphoria / physiology* Factor Analysis, Statistical Female Humans Male Middle Aged Multiple Sclerosis / physiopathology*, psychology* Neuropsychological Tests* Personality Assessment Psychometrics Questionnaires Reproducibility of Results Severity of Illness Index |
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