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Constrictive Pericarditis as a Never Ending Story: What's New?
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PMID:  22493608     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Nowadays, we have a better understanding of the natural history of constrictive pericarditis such as transient constriction. In addition, we have acquired the correct understanding of hemodynamic features that are unique to constrictive pericarditis. This understanding has allowed us to diagnose constrictive pericarditis reliably with Doppler echocardiography and differentiation between constrictive pericarditis and restrictive cardiomyopathy is no longer a clinical challenge. The advent of imaging modalities such as CT or MR is another advance in the diagnosis of constrictive pericarditis. We can accurately measure pericardial thickness and additional information such as the status of coronary artery and the presence of myocardial fibrosis can be obtained. We no longer perform cardiac catheterization for the diagnosis of constrictive pericarditis. However, these advances are useless unless we suspect and undergo work-up for constrictive pericarditis. In constrictive pericarditis, the most important diagnostic tool is clinical suspicion. In a patient with signs and symptoms of increased systemic venous pressure i.e. right sided heart failure, that are disproportionate to pulmonary or left sided heart disease, possibility of constrictive pericarditis should always be included in the differential diagnosis.
Authors:
Dae-Won Sohn
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Publication Detail:
Type:  Journal Article     Date:  2012-03-26
Journal Detail:
Title:  Korean circulation journal     Volume:  42     ISSN:  1738-5555     ISO Abbreviation:  Korean Circ J     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-11     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101247141     Medline TA:  Korean Circ J     Country:  Korea (South)    
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Languages:  eng     Pagination:  143-50     Citation Subset:  -    
Affiliation:
Cardiovascular Center, Seoul National University Hospital, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
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Journal Information
Journal ID (nlm-ta): Korean Circ J
Journal ID (iso-abbrev): Korean Circ J
Journal ID (publisher-id): KCJ
ISSN: 1738-5520
ISSN: 1738-5555
Publisher: The Korean Society of Cardiology
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Copyright © 2012 The Korean Society of Cardiology
open-access:
Print publication date: Month: 3 Year: 2012
Electronic publication date: Day: 26 Month: 3 Year: 2012
Volume: 42 Issue: 3
First Page: 143 Last Page: 150
ID: 3318085
PubMed Id: 22493608
DOI: 10.4070/kcj.2012.42.3.143

Constrictive Pericarditis as a Never Ending Story: What's New?
Dae-Won Sohn, MDA1
Cardiovascular Center, Seoul National University Hospital, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Correspondence: Correspondence: Dae-Won Sohn, MD, Cardiovascular Center, Seoul National University Hospital, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel: 82-2-2072-2855, Fax: 82-2-764-4281, dwsohn@snu.ac.kr

Introduction

In typical constrictive pericarditis, diastolic filling of the heart is inhibited because of chronic fibrous thickening of the wall of pericardial sac. Descriptions of diseases of the pericardium have a long history (Table 1) and date back as far as Egyptian and Greek civilizations. Historically, the eponym "Pick's disease" was given to constrictive pericarditis with ascites and hepatomegaly,1) which implies that these patients may be misdiagnosed as having chronic liver disease. In the past, we also experienced a patient who was referred under the impression of nephrotic syndrome because of the combin-ation of ascites and proteinuria, and turned out to have constrictive pericarditis. Although coming to an accurate diagnosis of constrictive pericarditis is sometimes challenging, efforts to get a correct diagnosis is critical as this condition can usually be completely cured.


Etiology

Most causes of acute pericarditis (Table 2) could be a possible cause of chronic constrictive pericarditis. However, sometimes patients with idiopathic/viral pericarditis are unduly informed of developing constrictive pericarditis. In a study assessing the risk of constrictive pericarditis following a first episode of acute pericarditis2) in 500 patients over a mean follow-up of six years (24 to 120 months), constrictive pericarditis developed in only 2 of 416 patients with idiopathic/viral pericarditis. Even in recurrent pericarditis, the development of constrictive pericarditis was low in this subset of patients.3)

The causes of constrictive pericarditis can be varied. Tuberculosis accounted for 49% of cases of constrictive pericarditis in a series reported in 1962,4) but tuberculosis is now only a rare cause of constrictive pericarditis in developed countries. However, it should be considered as a possible etiology in countries where prevalence of active tuberculosis is still high and in patients with HIV infection. In the modern era, we are more concerned about etiologies such as post-cardiac surgery or post-radiation therapy. This is not only because of the recent increase in the incidence of these etiologies, but also because of the relatively poor prognosis of these entities.5), 6)


Diagnosis

Traditionally, diagnosis of constrictive pericarditis has been accomplished by demonstrating both, 1) calcified pericardium or increase in pericardial thickness, and 2) presence of constrictive physiology.

Calcified pericardium or increase in pericardial thickness

This can be done by a number of imaging modalities. However, in a recent report, 18% of patients (26 out of 143 patients) showed normal thickness pericardium in proven constrictive pericarditis. Therefore, one should not exclude the possibility of constrictive pericarditis even in the absence of this finding if clinically suspected.

Although not sensitive enough for the clinician to be satisfied, chest X-ray findings (Fig. 1) can occasionally give us the possibility of constrictive pericarditis, that may have been missed. To get the best information from the chest X-ray, both lateral and PA projection images should be obtained.

To get direct visualization of the pericardium, direct measurement of pericardial thickness can be performed by either computed tomographic (CT) scanning (Fig. 2) or magnetic resonance (MR) im-aging.1), 7-10) One can consider the pericardium to be thickened when the pericardial thickness is greater than 2 mm in diameter. In addition to the fact that a considerable proportion of patients with constrictive pericarditis can show a normal thickness pericardium as already mentioned, the finding of a thickened pericardium is not necessarily diagnostic of constrictive pericarditis. Some patients may have pericardial thickening without evidence of constriction. For example, some degree of pericardial reaction can manifest as an increase in the pericardial thickness, and may be present without a hemodynamic effect in patients who have had radiation therapy or an open heart operation.

Both CT and MR can give anatomic information other than pericardial thickness, such as critical vascular abnormality or extent of lung injury. In addition to these advantages, when the CT is utilized, one can avoid the need for invasive coronary angiography in those with normal CT coronary angiography. One potential advantage of MR over CT is that it can obtain information that can be derived from the late gadolinium enhancement findings. MRI can give us information about pericardial inflammation and pericardial-myocardial adherence11) as well as myocardial fibrosis that may be involved in the clinical improvement after pericardiectomy.

Presence of constrictive physiology

In the past, hemodynamic findings that are peculiar to constriction had not been accurately understood.12), 13) Based on the incomplete understanding of constrictive physiology, it had been our understanding that cardiac catheterization is the gold standard for reliable evaluation of the presence or absence of constrictive physiology. Cardiac catheterization findings include an increase and equalization of end diastolic pressures in all four cardiac chambers, a dip and plateau pattern in the ventricular pressure curves, and rapid x and y descents in the atrial pressure curves (Fig. 3). As these findings are not peculiar to the constrictive physiology, these findings also may be present in patients with restrictive cardiomyopathy. Therefore, differentiation between constrictive pericarditis and restrictive cardiomyopathy has always been a challenging clinical problem.

In 1989, Hatle et al.14) reported the two characteristic features in constrictive pericarditis. Firstly, they showed dissociation between intrathoracic and intracardiac pressures. In normal persons, inspiration causes a decrease in both the intrathoracic and intracardiac pressures. Therefore, during inspiration, there is a simultaneous fall in intrathoracic and intracardiac pressures and, there is no change in the driving pressure from the lungs into the left-sided chambers. However, in a patient with constrictive pericarditis, decrease in intrathoracic pressure is not transmitted to the left sided chambers because of the rigid pericardium, and during inspiration, there is a lower driving force from the lungs into the left side of the heart and the left ventricle becomes underfilled. Secondly, enhanced ventricular interaction can also occur. As both ventricles are sharing the same limited space, chamber size and function of one ventricle affects the other ventricle, and this interaction is enhanced in constrictive pericarditis. In patients with constrictive pericarditis, the left ventricle is under filled during inspiration and there is a reciprocal increase in filling of the right ventricle. Conversely, during expiration there is decreased filling of the right ventricle and increased filling of the left ventricle.

These two unique features of constrictive pericarditis can accurately be evaluated by Doppler echocardiography.15), 16) As these features are not present in restrictive cardiomyopathy, differentiation between constrictive pericarditis and restrictive cardiomyopathy can reliably be done by Doppler echocardiography. Doppler echocardiographic findings include 1) prominent (usually over 25%) increase in mitral E velocity during expiration and decrease during inspiration and, 2) increase in diastolic flow reversal in the hepatic venous flow during expiration (Figs. 4 and 5).

Pitfalls in Doppler echocardiography

Although Doppler echocardiography is a potent tool in detecting the presence of constrictive physiology, one should keep in mind se-veral pitfalls, for example respiratory variation in the mitral inflow may not be present in about 20% of the patients.17), 18) In certain proportion of these patients without respiratory variation in the mitral inflow, absence of respiratory variation may be due to the volume status of the patient. Therefore, respiratory variation can be elicited by preload reduction with semi-recumbent (rather than supine) positioning or diuretic administration in patients with markedly elevated left atrial pressure.19) In the opposite situation with volume depleted state, respiratory variation can be elicited by leg raising (Fig. 6). Another pitfall is that respiratory variation in the mitral inflow is not unique to constrictive pericarditis. This variation can be seen in chronic obstructive lung disease and in situations when the pericardial constraint becomes manifested by severe left or right ventricular dilatations. A final pitfall is that in the evaluation of hepatic vein flow, one should be cautious in patients with rapid respiratory rate as the respiratory cycle from inspiration to expiration may change in every cardiac cycle, therefore, mimicking constrictive physiology (Figs. 7 and 8).

Role of mitral annulus velocity in constrictive pericarditis

Although we can reliably diagnose constrictive pericarditis with Doppler echocardiography, it is not always easy to get diagnostically meaningful Doppler signals because of low image quality and patient cooperation is needed in the evaluation of respiratory variation. Therefore, evaluation of mitral annulus velocity (E' velocity) in patients with constrictive pericarditis is sometimes very useful. In constrictive pericarditis, as the dilatation of chambers in the short axis direction is limited because of the thickened pericardium, there is a compensatory increase in chamber dilatations in the long axis direction. Therefore, E' is usually well preserved or even accentuated (Fig. 9).18) This unique feature of mitral annulus velocity in constrictive pericarditis is especially useful in differential diagnosis between constrictive pericarditis and restrictive cardiomyopathy. In contrast to constrictive pericarditis, restrictive cardiomyopathy, which is a myocardial disease, nearly always shows depressed E' velocity.17), 20) In addition to the preserved or accentuated E' velocity in constrictive pericarditis, a recent study showed that medial E' velocity in patients with constrictive pericarditis is higher than the lateral E' velocity, which is the opposite phenomenon in usual situations, and this phenomenon is reported to be useful during the diagnosis.21), 22)

Because of the well preserved or even accentuated E' velocity in constrictive pericarditis, we should keep in mind that, E/E' ratio which has been widely used in the estimation of left ventricular filling pressure shows an inverse relationship to left ventricular filling pressure.23) Therefore, it cannot be applied in the estimation of filling pressure in patients with constrictive pericarditis.

Traditional echocardiographic findings

As discussed in Doppler echocardiography, interventricular dependence is exaggerated in constrictive pericarditis, which implies that in the M-mode or 2D echocardiography respiratory variation of the ventricular size can be observed (Fig. 10). However, before the advent of our current understanding of constrictive physiology, a number of other indirect signs have been used in the diagnosis of constrictive pericarditis and these findings are as follows: 1) thickening of the pericardium, which may be more reliably estimated by transesophageal echocardiography24); 2) abnormal septal motion; 3) flattening of the left ventricular posterior wall during diastole; and 4) dilatation of the inferior vena cava.25), 26) Although one can suspect the presence of constrictive pericarditis with M-mode or 2D echocardiographic findings, these findings are not sensitive or specific for the confirmative diagnosis of constriction. Therefore, one should resort to echo-Doppler findings for the diagnosis.

History taking and physical examination

History taking and physical examination are not an obsolete process in the diagnosis of constrictive pericarditis. When encountered by physical findings representing increased systemic venous pressure, such as increase in jugular venous pressure, ascites, hepatosplenomegaly and edema, the possibility of constrictive pericarditis should considered. For example, patients with constrictive pericarditis can be accompanied by proteinuria of the nephrotic range and protein loosing enteropathy. If the physician does not notice increased jugular pressure in the physical examination, the patient may unnecessarily undergo examination such as kidney biopsy or colonoscopic examination.

It is worth mentioning that in addition to increased pressure, jugular pressure waveform is quite characteristic. As the right atrial pressure waveform shows an M or W shape because of the prominent Y descent in addition to the preserved X descent, jugular venous waveform is seen by the naked eye as "hyperdynamic" as we usually perceive descent as a collapse. Therefore, it is not difficult to tell the pressure waveform in patients with constrictive pericarditis as abnormal.

During history taking, possible predisposing conditions that can lead to constrictive pericarditis should be focused on.


Treatment and Outcome

Symptoms related to constrictive pericarditis can be improved by removing the pericardium surgically and pericardiectomy is the only definitive treatment option for patients with chronic constrictive pericarditis. Medical therapy such as diuresis may be used as a temporary measure and for patients who cannot undergo surgery.

However, constriction may be transient or reversible in a minority of patients with constrictive pericarditis. Thus, patients with newly diagnosed constrictive pericarditis may be given a trial of conservative management for two to three months before pericardiectomy is recommended.

Even in patients who are planning for pericardiectomy, deciding the timing of surgery is sometimes difficult because pericardiectomy is technically difficult if pericarditis is still in the effusive or adhesive state. On the other hand, if the surgery is performed too late, lower extremity edema may persist even after the relief of systemic venous hypertension because of deep vein incompetence. Here, MR imaging might be helpful in obtaining information about the state of pericardial inflammation and pericardial-myocardial adherence.11) Traditionally, pericarditis has been classified as acute, subacute and chronic (Table 3), and we used to rely on the stage of pericarditis when considering pericardiectomy.

Pericardiectomy has a significant operative mortality of 5-7% even recently.27), 28) Therefore, recommendation of surgery should be done very cautiously in patients with either mild or very advanced disease and in whom prognosis after pericardiectomy was reported to be poor,5), 6) e.g., those with radiation-induced constriction, myocardial dysfunction, significant renal dysfunction, or mixed const-rictive-restrictive disease. In the past, heavy calcification on chest X-ray had been regarded as a relative contraindication to surgery.

Transient constrictive pericarditis

A subset of patients with constrictive pericarditis undergoes spontaneous resolution of constrictive pericarditis or responds to medical therapy29) usually in average 8 weeks. The causes for transient constrictive pericarditis are diverse, the most common being prior cardiovascular surgery (25%). Most frequent treatment has been nonsteroidal anti-inflammatory drugs. A recent study30) showed a promising role of MR imaging in predicting which patients with constrictive pericarditis will have reversal or resolution of the process. In this study, late gadolinium enhancement pericardial thickness ≥3 mm had 86% sensitivity and 80% specificity in predicting reversibility.

Occult constrictive pericarditis and effusive-constrictive pericarditis

Diagnosis of occult constrictive pericarditis31) had made symptomatic patients whose hemodynamic findings are not overt at the resting state but could have been elicited by expanding volume status by saline infusion. It was also reported that symptoms of the patients improved after pericardiectomy. We can understand the hemodynamic status in these patients, but it is uncertain that patient's symptoms were related to the occult constriction.

Diagnosis of effusive-constrictive pericarditis can be made in patients with hemodynamic constriction who also have significant amount of pericardial effusion. Hemodynamically, tamponade and constrictive physiology can co-exist. Therefore, when only the presence of pericardial effusion was appreciated in patient with this entity, drainage of pericardial effusion will not result in the complete resolution of systemic congestion. Therapeutically, this situation usually implies that an active inflammatory process is ongoing. Therefore, it is usually not an optimal timing for pericardiectomy and depending on the etiology, constrictive physiology can be reversible.


Notes

The author has no financial conflicts of interest.

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Article Categories:
  • Review

Keywords: Pericarditis, constrictive, Echocardiography, Doppler, Hemodynamics.

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