| Constitutive Activation of IKKβ in Adipose Tissue Prevents Diet-Induced Obesity in Mice. | |
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MedLine Citation:
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PMID: 22067324 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The IκB kinase β (IKKβ) is a master kinase involved in obesity-related inflammation and insulin resistance through nuclear factor κB dependent and independent pathways. However, the effect of IKKβ activation in adipose tissue, the organ critical for storage of excessive energy and initiation of inflammatory responses in the context of obesity, on systemic insulin sensitivity and metabolism, has not been investigated. In our study, we found that mice overexpressing the constitutively active IKKβ in adipose tissue under the control of murine adipocyte fatty acid binding protein (aP2) promoter were protected from age-related and diet-induced body weight gains, despite increased food intake. The aP2-IKKβ SE mice have significantly reduced weights in all white adipose tissue depots and reduced triglyceride contents in adipose tissue, liver, and muscle. Despite increased systemic and tissue inflammation, aP2-IKKβ SE mice displayed decreased blood glucose levels, improved glucose, and insulin tolerance. This may be at least partially attributable to increased energy expenditure. Histological analysis revealed presence of many small adipocytes in white adipose tissue of aP2-IKKβ SE mice fed on high-fat diet. Furthermore, transgenic expression of IKKβ in adipose tissue improved high-fat diet-induced hepatosteatosis. Collectively, increased energy expenditure and reduced plasma free fatty acid levels may contribute to enhanced systemic insulin sensitivity in aP2-IKKβ SE mice. Our study demonstrates that presence of inflammation in adipose tissue before the development of obesity has beneficial effect on metabolism. |
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Authors:
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Ping Jiao; Bin Feng; Jie Ma; Yaohui Nie; Erin Paul; Yujie Li; Haiyan Xu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-8 |
Journal Detail:
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Title: Endocrinology Volume: - ISSN: 1945-7170 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hallett Center for Diabetes and Endocrinology (P.J., B.F., Y.N., Y.L., H.X.), Rhode Island Hospital and Division of Gastroenterology (J.M.), Brown Medical School, and Department of Molecular Biology (E.P.), Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02903; School of Pharmaceutical Sciences (P.J., J.M.), Jilin University, Changchun 130012, China; and Key Laboratory of Agricultural Animal Genetics (B.F.), Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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