| Constitutional inv(3) in myelodysplastic syndromes. | |
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MedLine Citation:
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PMID: 20542563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The constitutional pericentric inversion on chromosome 3, inv(3), is rarely found in a normal population. The aim of our study was to investigate its possible link to hematologic malignancy. Chromosomes from bone marrow cells in 890 patients with hematologic disorders were analyzed with the Q-banding technique. Thirty-four patients had inv(3) (3.8%). In 241 patients with myelodysplastic syndromes the frequency was 6.2% as opposed to 2.9% in the remaining 649 patients (p=0.02). The increased frequency of inv(3) in patients with myelodysplastic syndromes indicates that inv(3) could be a risk factor for the development of the disease. |
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Authors:
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Caroline Gahrton; Hareth Nahi; Monika Jansson; Ann Wallblom; Evren Alici; Tolga Sutlu; Jan Samuelsson; Gösta Gahrton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-09 |
Journal Detail:
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Title: Leukemia research Volume: 34 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 1627-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, Karolinska Institutet Huddinge, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Banding Chromosome Inversion* Chromosomes, Human, Pair 3 / genetics* Female Humans Male Myelodysplastic Syndromes / genetics* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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