| Constituents of Picralima nitida display pronounced inhibitory activities against asexual erythrocytic forms of Plasmodium falciparum in vitro. | |
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MedLine Citation:
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PMID: 8953424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiplasmodial activities of organic and aqueous extracts from the West African plant Picralima nitida (Apocynaceae) were examined in an in vitro model, against asexual erythrocytic forms of Plasmodium falciparum. Root and leaf extracts of this species had never been examined before. Several extracts displayed considerable inhibitory activities. The highest activities were found in root, stem bark and fruit rind extracts, with IC50 values of 0.188, 0.545 and 1.581 micrograms/ml, respectively. The leaf and seed extracts generally yielded much lower activity or were completely inactive. |
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Authors:
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G François; L Aké Assi; J Holenz; G Bringmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 54 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-10 Completed Date: 1997-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 113-7 Citation Subset: IM |
Affiliation:
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Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimalarials / pharmacology* Erythrocytes / parasitology* Humans Malaria, Falciparum / blood, drug therapy Plant Extracts / pharmacology* Plants, Medicinal* Plasmodium falciparum / drug effects*, growth & development |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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