Document Detail


Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells.
MedLine Citation:
PMID:  20393003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A bioassay-guided separation protocol, including the testing of the extracts, fractions and pure compounds for their ability to inhibit P-glycoprotein (the efflux pump responsible for the multidrug resistance of the used cell line) of mouse lymphoma cells containing the human efflux pump gene MDR1, led to the isolation of seven compounds from the chloroform and ethyl acetate soluble fractions of the methanolic extract of Carpobrotus edulis. The compounds were identified by 1D, 2D NMR and MS investigations as triterpens (beta-amyrin, uvaol and oleanolic acid), monogalactosyldiacylglycerol, catechin, epicatechin and procyanidin B5. Uvaol was the most effective and promising compound in the reversal of multidrug resistance in MDR mouse lymphoma cell line.
Authors:
A Martins; A Vasas; Zs Schelz; M Viveiros; J Moln?r; J Hohmann; L Amaral
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  829-35     Citation Subset:  IM    
Affiliation:
Unit of Mycobacteriology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua Junqueira 96, 1349-008 Lisbon, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Aizoaceae / chemistry*
Animals
Galactolipids / pharmacology
Humans
Leukemia L5178 / drug therapy,  genetics,  metabolism
Lymphoma, T-Cell / drug therapy*,  genetics,  metabolism*
Methanol / chemistry
Mice
Oleanolic Acid / pharmacology
P-Glycoprotein / antagonists & inhibitors*,  genetics,  metabolism
Plant Extracts / chemistry,  isolation & purification,  pharmacology*
Plant Leaves / chemistry
Rhodamine 123 / pharmacokinetics
Transfection
Triterpenes / pharmacology
Chemical
Reg. No./Substance:
0/Galactolipids; 0/P-Glycoprotein; 0/Plant Extracts; 0/Triterpenes; 0/monogalactosyldiacylglycerol; 508-02-1/Oleanolic Acid; 545-46-0/uvaol; 62669-70-9/Rhodamine 123; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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