| Constipation in Parkinson's disease: objective assessment and response to psyllium. | |
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MedLine Citation:
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PMID: 9399219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the reliability of patient history and the effect of psyllium on symptoms and colorectal function in 12 patients with Parkinson's disease (PD) and constipation. In all but two, constipation anteceded the development of parkinsonian symptoms. A comparison with prospectively obtained stool diaries confirmed the patients' reported constipation in 7 of the 12 patients. Those patients with confirmed constipation had lower stool weights and reported more straining at stool. Measures of colonic and anorectal function were similar in those who were truly constipated and those who were not. Among those PD subjects with confirmed constipation, psyllium increased stool frequency and weight but did not alter colonic transit or anorectal function. We conclude that prospectively obtained stool diaries should be employed to confirm constipation in PD and that psyllium produces both subjective and objective improvements in constipation related to PD. |
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Authors:
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W Ashraf; R F Pfeiffer; F Park; J Lof; E M Quigley |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 12 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-10 Completed Date: 1998-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 946-51 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-2000, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anal Canal / anatomy & histology, physiology Cathartics / therapeutic use* Constipation / complications*, drug therapy* Defecation Female Humans Male Middle Aged Parkinson Disease / complications* Prospective Studies Psyllium / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cathartics; 8063-16-9/Psyllium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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