Document Detail


Constant light induces alterations in melatonin levels, food intake, feed efficiency, visceral adiposity, and circadian rhythms in rats.
MedLine Citation:
PMID:  19761654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Melatonin levels, metabolic parameters, circadian rhythm activity patterns, and behavior were observed in rats subjected to a 12-h/12-h light/dark cycle (LD) compared to animals exposed to continuous dark (DD) or continuous light (LL). LD and DD animals were similar in melatonin levels, food intake, relative food intake, feed efficiency, water intake, circadian activity levels, and behavior. LL animals had lower melatonin levels in the subjective dark compared to LD and DD animals. Food intake, relative food intake, and water intake values were lower and feed efficiency was more positive in LL animals compared to LD and DD animals. In addition, LL animals exhibited greater visceral adiposity than the other two groups. The circadian rhythmicity of activity became free-running in LL animals and there was a decrease in overall activity. Notable behavioral changes in LL animals were an increase in irritability and excitability. Results indicate that a decrease in melatonin levels and concomitant changes in metabolism, circadian rhythms, and behavior are consequences of exposure to constant light.
Authors:
Cyrilla H Wideman; Helen M Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  12     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-18     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-40     Citation Subset:  IM    
Affiliation:
Department of Biology, John Carroll University, 20700 North Park Blvd., Cleveland, OH 44118, USA. cwideman@jcu.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological / radiation effects*
Adiposity / radiation effects*
Algorithms
Animals
Body Weight / radiation effects
Circadian Rhythm / radiation effects*
Drinking / radiation effects
Eating / radiation effects*
Intra-Abdominal Fat / radiation effects
Light / adverse effects*
Male
Melatonin / blood,  metabolism*
Motor Activity / radiation effects*
Rats
Rats, Long-Evans
Sleep Deprivation
Telemetry
Time Factors
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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