Document Detail

Consolidation of human memory over decades revealed by functional magnetic resonance imaging.
MedLine Citation:
PMID:  11600889     Owner:  NLM     Status:  MEDLINE    
Medial temporal lobe (MTL) lesions typically produce retrograde amnesia characterized by the disproportionate loss of recently acquired memories. Temporally graded memory loss is interpreted traditionally as evidence for a consolidation process guided by the MTL. Here, using functional magnetic resonance imaging (fMRI), we show temporally graded changes in MTL activity in healthy older adults taking a famous faces remote memory test. Evidence for temporally graded change in the hippocampal formation was mixed, suggesting it may participate only in consolidation processes lasting a few years. Entorhinal cortex was associated with temporally graded changes extending up to 20 years. These findings support the basic tenets of consolidation theory and suggest that the entorhinal cortex, rather than the hippocampal formation, participates in memory consolidation over decades.
F Haist; J Bowden Gore; H Mao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature neuroscience     Volume:  4     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-45     Citation Subset:  IM    
Laboratory for Research on the Neuroscience of Autism, Children's Hospital Research Center, 8110 La Jolla Shores Drive (Suite 201), La Jolla, California 92037, USA.
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MeSH Terms
Aging / physiology
Brain Mapping
Entorhinal Cortex / physiology*
Famous Persons
Hippocampus / physiology*
Magnetic Resonance Imaging*
Memory / physiology*
Mental Recall
Middle Aged
Temporal Lobe / physiology*
Time Factors
Comment In:
Nat Neurosci. 2001 Nov;4(11):1057-8   [PMID:  11687811 ]

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