Document Detail

Consistent lowering of clotting factors for the treatment of acute cardiovascular syndromes and hypercoagulability: a different pathophysiological approach.
MedLine Citation:
PMID:  11724509     Owner:  NLM     Status:  MEDLINE    
Hypercoagulability is a key contributor to acute cardiovascular syndromes and to various microcirculatory disorders. The use of heparin-mediated extracorporeal low-density lipoprotein/fibrinogen precipitation (HELP) apheresis makes a controlled, immediately effective reduction of clotting factors possible, and induces subsequent positive effects on plasma viscosity, erythrocyte aggregation, and microcirculation. Oxygen supply to an ischemic artery can thus be increased without hemodilution, qualifying the HELP system as a possible therapeutic tool in the treatment of acute cardiovascular syndromes and microcirculatory disorders.
B R Jaeger; P Goehring; J Schirmer; S Uhrig; P Lohse; E Kreuzer; B Reichart; D Seidel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis     Volume:  5     ISSN:  1091-6660     ISO Abbreviation:  Ther Apher     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-11-28     Completed Date:  2002-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9706703     Medline TA:  Ther Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252-9     Citation Subset:  IM    
Institute of Clinical Chemistry, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Germany.
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MeSH Terms
Blood Coagulation / physiology
Blood Coagulation Disorders / therapy*
Blood Coagulation Factors / analysis*
Cardiovascular Diseases / therapy*
Coronary Artery Disease / prevention & control
Coronary Thrombosis / prevention & control
Hypercholesterolemia / therapy*
Middle Aged
Plasmapheresis / methods*
Reg. No./Substance:
0/Blood Coagulation Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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