| Consistency test of the cell cycle: roles for p53 and EGR1. | |
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MedLine Citation:
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PMID: 22315347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mammalian cells are constantly exposed to multiple mitogens and, hence, have developed machineries that help them ignore fortuitous signals. In a recent report in Molecular Cell, we highlighted the molecular details of such a noise-reduction filter, including roles for EGR1, AKT, and p53. Brief exposure to a mitogen drives formation of inhibitory p53-chromatin complexes, which are disabled only if the growth factor is still present several hours later. We propose that this "consistency test" prevents repeated division cycles of normal cells but might become defective in most cancer cells. |
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Authors:
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Yaara Zwang; Moshe Oren; Yosef Yarden |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-02-07 |
Journal Detail:
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Title: Cancer research Volume: 72 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-04-27 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 1051-4 Citation Subset: IM |
Affiliation:
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Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Cell Division* Chromatin / chemistry Early Growth Response Protein 1 / physiology* Genes, p53 Humans Mutation Neoplasms / pathology* Tumor Suppressor Protein p53 / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R37 CA072981/CA/NCI NIH HHS; R37 CA072981-16/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/EGR1 protein, human; 0/Early Growth Response Protein 1; 0/Tumor Suppressor Protein p53 |
| Comments/Corrections | |
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