Document Detail

Considerations in evaluating human spermatogenesis on the basis of total sperm per ejaculate.
MedLine Citation:
PMID:  19443909     Owner:  NLM     Status:  MEDLINE    
Total number of sperm per ejaculate (TSperm) is an important measure for clinicians to provide advice to patient couples. However, TSperm per hour of abstinence (TSperm/h) is a better measure for epidemiologist-andrologist teams or clinicians to evaluate spermatogenesis because it is a rate function. This review looks at the interplay and impacts of rate of sperm accumulation in the excurrent duct system, abstinence interval, sexual arousal, and masturbation vs intercourse on observed TSperm. It also examines why and when TSperm/h might provide a meaningful quantitative evaluation of spermatogenesis (ie, rate of sperm production). There is no doubt that TSperm increases with longer abstinence, and in different men plateaus after 2-9 days. Clinicians wishing to maximize number of fully functional sperm available during intercourse, or for artificial insemination, might wish to recommend 6-7 days of abstinence. Diagnostically, the important feature is TSperm/h. After abstinence interval exceeds 64-72 hours, TSperm/h has started to decline in most nonoligozoospermic men as rate of sperm accumulation in the excurrent ducts approaches zero; apparently increasingly more sperm are voided in urine. Clinicians or epidemiologist-andrologist teams wishing to have optimal distinction among individuals with high, typical, or low sperm production (ie, normal or abnormal spermatogenesis) should accurately measure TSperm/h for samples provided after 42-54 hours' abstinence (never <or=36 or >64 hours). Longer abstinence intervals reward men with poor sperm production, because sperm accumulate in the excurrent ducts for 7 days or more of abstinence, and penalize men with good sperm production, because after 3 days or less of abstinence their excurrent ducts probably are full.
Rupert P Amann
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-05-14
Journal Detail:
Title:  Journal of andrology     Volume:  30     ISSN:  1939-4640     ISO Abbreviation:  J. Androl.     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-10-21     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  626-41     Citation Subset:  IM    
Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado, USA.
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MeSH Terms
Epididymis / cytology,  physiology
Infertility, Male / etiology,  therapy
Semen / cytology*
Sexual Abstinence
Sperm Count*
Spermatogenesis / physiology*
Testicular Diseases / complications
Time Factors
Vas Deferens / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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