| Considerations on the Performance of Immunohistochemistry for Mismatch Repair Gene Proteins in Cases Sebaceous Neoplasms and Keratoacanthomas With Reference to Muir-Torre Syndrome. | |
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MedLine Citation:
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PMID: 22123265 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cutaneous sebaceous tumors, as well as keratoacanthomas, are associated with Muir-Torre syndrome (MTS). Visceral neoplasias are a feature of this syndrome; thus, early detection using a cutaneous biopsy is very important in dermatopathology. A dermatopathologist can apply different techniques in such cases, including immunohistochemistry for several mismatch repair proteins or molecular studies for microsatellites instability. However, in a world where economic resources play an increasing role, how discriminative the dermatopathologist should be in investigating cutaneous lesions that may indicate MTS is not a trivial matter. Although previous reports have presented algorithms on MTS focusing on a multidisciplinary approach, our report emphasizes the role of the dermatopathologist and tries to answer several questions that could arise when facing a cutaneous tumor that may indicate MTS. |
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Authors:
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Angel Fernandez-Flores |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: - ISSN: 1533-0311 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Anatomic Pathology, Hospital El Bierzo. Ponferrada, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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