Document Detail


A consideration of genetic mechanisms behind the development of hypertension in blacks.
MedLine Citation:
PMID:  23397215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is a more serious disease in blacks. The determinants of the blood pressure (BP) may be uniquely different from those in whites. The characteristic low-renin, salt-sensitive hypertension of blacks is consistent with the kidney reabsorbing additional sodium (Na), which leads to an expanded plasma volume that drives the BP. Mechanisms considered are genetically based. These include: (1) the intra-renal renin-angiotensin system (RAS), one based on molecular variations in angiotensinogen; (2) the Na, K, 2Cl cotransporter (NKCC2) and its regulators in the thick ascending limb, which are associated with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks. To achieve a state of hypertension, an increase in Na uptake in proximal nephron regions may require a distal nephron that does not fully adjust due to less than adequate suppression of aldosterone production.
Authors:
Wanzhu Tu; J Howard Pratt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  15     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-19     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  108-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics*
Apolipoproteins / genetics
Blood Pressure / genetics
Humans
Hypertension / ethnology,  genetics*
Kidney / metabolism*
Lipoproteins, HDL / genetics
Molecular Motor Proteins / genetics
Myosin Heavy Chains / genetics
Renin-Angiotensin System / genetics
Sodium-Potassium-Chloride Symporters / genetics
Solute Carrier Family 12, Member 1
Grant Support
ID/Acronym/Agency:
M01 RR000750/RR/NCRR NIH HHS; R01 HL035795/HL/NHLBI NIH HHS; R01 HL095086/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/APOL1 protein, human; 0/Apolipoproteins; 0/Lipoproteins, HDL; 0/MYH9 protein, human; 0/Molecular Motor Proteins; 0/SLC12A1 protein, human; 0/Sodium-Potassium-Chloride Symporters; 0/Solute Carrier Family 12, Member 1; EC 3.6.4.1/Myosin Heavy Chains
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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