Document Detail

Conserved segmental expression of Krox-20 in the vertebrate hindbrain and its relationship to lineage restriction.
MedLine Citation:
PMID:  1688180     Owner:  NLM     Status:  MEDLINE    
The zinc-finger gene Krox-20 is expressed in two alternating segments, rhombomeres (r) 3 and 5, in the developing mouse hindbrain. This expression pattern is established prior to rhombomere formation in the mouse, but it is not known how the timing of expression relates to cellular events of segmentation, such as lineage restriction. We have cloned Krox-20 sequences from Xenopus and the chick and shown that its alternating expression pattern is conserved in these systems, suggesting that its role in hindbrain development is conserved. Analysis of the early stages of Krox-20 expression in the chick show that both domains of expression precede the restriction of cell lineage to specific rhombomeres, consistent with a role of this gene in early events of hindbrain segmentation. The finding that expression is not coincident with lineage restriction indicates that early expression may not reflect an irreversible commitment of cells to r3 and r5 and/or may be mosaic.
M A Nieto; L C Bradley; D G Wilkinson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  Suppl 2     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1991  
Date Detail:
Created Date:  1993-01-04     Completed Date:  1993-01-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK.
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MeSH Terms
Amino Acid Sequence
Cell Differentiation / genetics*
Chick Embryo
Conserved Sequence / physiology*
Gene Expression / physiology*
Genes, Homeobox / genetics*
In Situ Hybridization, Fluorescence
Molecular Sequence Data
Neural Crest / physiology
Rhombencephalon / embryology*
Sequence Homology, Amino Acid

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