| Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats. | |
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MedLine Citation:
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PMID: 2497298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenic Neisseria, N. gonorrhoeae and N. meningitidis, possess an outer membrane protein (OMP), designated H.8, with a conserved monoclonal antibody (MAb)-binding epitope. We determined the DNA sequence of a gonococcal H.8 gene, and confirmed the relationship between the cloned gene and the H.8 OMP by constructing a gonococcal mutant lacking H.8. The predicted H.8 OMP is a lipoprotein 71 amino acids in length, composed of 13 repeats of a consensus sequence AAEAP with perfect 5-residue periodicity. The AAEAP units form a repeating epitope that comprises the entire predicted sequence of the protein. |
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Authors:
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J P Woods; S M Spinola; S M Strobel; J G Cannon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular microbiology Volume: 3 ISSN: 0950-382X ISO Abbreviation: Mol. Microbiol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-06-16 Completed Date: 1989-06-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8712028 Medline TA: Mol Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill 27599. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/X12627 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Bacterial Outer Membrane Proteins / genetics* Base Sequence Cloning, Molecular DNA, Bacterial Genes* Genes, Bacterial* Immunoblotting Lipoproteins / genetics Molecular Sequence Data Mutation Neisseria gonorrhoeae / genetics* Neisseria meningitidis / genetics* Repetitive Sequences, Nucleic Acid* |
| Grant Support | |
ID/Acronym/Agency:
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AI07001/AI/NIAID NIH HHS; AI15036/AI/NIAID NIH HHS; AI23830/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Outer Membrane Proteins; 0/DNA, Bacterial; 0/H.8 protein (Neisseria); 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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