Document Detail


Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats.
MedLine Citation:
PMID:  2497298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenic Neisseria, N. gonorrhoeae and N. meningitidis, possess an outer membrane protein (OMP), designated H.8, with a conserved monoclonal antibody (MAb)-binding epitope. We determined the DNA sequence of a gonococcal H.8 gene, and confirmed the relationship between the cloned gene and the H.8 OMP by constructing a gonococcal mutant lacking H.8. The predicted H.8 OMP is a lipoprotein 71 amino acids in length, composed of 13 repeats of a consensus sequence AAEAP with perfect 5-residue periodicity. The AAEAP units form a repeating epitope that comprises the entire predicted sequence of the protein.
Authors:
J P Woods; S M Spinola; S M Strobel; J G Cannon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular microbiology     Volume:  3     ISSN:  0950-382X     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill 27599.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/X12627
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacterial Outer Membrane Proteins / genetics*
Base Sequence
Cloning, Molecular
DNA, Bacterial
Genes*
Genes, Bacterial*
Immunoblotting
Lipoproteins / genetics
Molecular Sequence Data
Mutation
Neisseria gonorrhoeae / genetics*
Neisseria meningitidis / genetics*
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
AI07001/AI/NIAID NIH HHS; AI15036/AI/NIAID NIH HHS; AI23830/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins; 0/DNA, Bacterial; 0/H.8 protein (Neisseria); 0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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