Document Detail

Conserved genetic pathways controlling the development of the diffuse endocrine system in vertebrates and Drosophila.
MedLine Citation:
PMID:  20005229     Owner:  NLM     Status:  MEDLINE    
The midgut epithelium is formed by absorptive enterocytes, secretory cells and endocrine cells. Each of these lineages is derived from the pluripotent progenitors that constitute the embryonic endoderm; the mature midgut retains pools of self-renewing stem cells that continue to produce all lineages. Recent findings in vertebrates and Drosophila shed light on the genetic mechanism that specifies the fate of the different lineages. A pivotal role is played by the Notch signaling pathway that, in a manner that appears to be very similar to the way in which Notch signaling selects neural progenitors within the neurectoderm, distinguishes the fate of secretory/endocrine cells and enterocytes. Proneural genes encoding bHLH transcription factors are expressed and required in prospective endocrine cells; activation of the Notch pathways restricts the number of these cells and promotes enterocyte development. In this review we compare the development of the intestinal endocrine cells in vertebrates and insects and summarize recent findings dealing with genetic pathways controlling this cell type.
Volker Hartenstein; Shigeo Takashima; Katrina L Adams
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-12-11
Journal Detail:
Title:  General and comparative endocrinology     Volume:  166     ISSN:  1095-6840     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-08-24     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009. Published by Elsevier Inc.
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MeSH Terms
Drosophila / cytology,  metabolism*
Drosophila Proteins / metabolism
Endocrine System / cytology,  metabolism*
Receptors, Notch / metabolism
Signal Transduction / physiology
Stem Cells / cytology,  metabolism
Vertebrates / metabolism*
Grant Support
R01 GM087373/GM/NIGMS NIH HHS; R01 GM087373-01/GM/NIGMS NIH HHS; R01 GM087373-02/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Drosophila Proteins; 0/Receptors, Notch

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