Document Detail

Conserved cardiogenic functions of the multitype zinc-finger proteins: U-shaped and FOG-2.
MedLine Citation:
PMID:  11597829     Owner:  NLM     Status:  MEDLINE    
Multitype zinc-finger proteins murine Friend of GATA-2 (FOG-2) and Drosophila U-shaped (Ush) are required for heart development. Both FOG proteins participate in signal transduction pathways that are essential for cardiogenesis. FOG-2 regulates signaling from the myocardium, which is required for the production of the coronary vasculature. Ush functions in a common pathway with the Heartless (Htl) fibroblast growth factor (FGF) receptor to control mesodermal cell migration, which is required for cardiogenic cell fate commitment. In vitro studies have demonstrated that both FOG proteins repress GATA factor transcriptional activation of cardiac promoters. These similarities provide further evidence for the conservation of gene functions during cardiogenesis in Drosophila and higher eukaryotes.
N Fossett; R A Schulz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  11     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, Graduate Program in Genes & Development, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.
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MeSH Terms
Conserved Sequence
DNA-Binding Proteins / physiology*
Drosophila / embryology,  genetics
Drosophila Proteins*
Gene Expression Regulation, Developmental / physiology*
Heart / embryology*
Receptors, Fibroblast Growth Factor / physiology
Signal Transduction
Transcription Factors / physiology*
Zinc Fingers / physiology*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Receptors, Fibroblast Growth Factor; 0/Transcription Factors; 0/u-shaped protein, Drosophila

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