| Conserved cardiogenic functions of the multitype zinc-finger proteins: U-shaped and FOG-2. | |
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MedLine Citation:
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PMID: 11597829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multitype zinc-finger proteins murine Friend of GATA-2 (FOG-2) and Drosophila U-shaped (Ush) are required for heart development. Both FOG proteins participate in signal transduction pathways that are essential for cardiogenesis. FOG-2 regulates signaling from the myocardium, which is required for the production of the coronary vasculature. Ush functions in a common pathway with the Heartless (Htl) fibroblast growth factor (FGF) receptor to control mesodermal cell migration, which is required for cardiogenic cell fate commitment. In vitro studies have demonstrated that both FOG proteins repress GATA factor transcriptional activation of cardiac promoters. These similarities provide further evidence for the conservation of gene functions during cardiogenesis in Drosophila and higher eukaryotes. |
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Authors:
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N Fossett; R A Schulz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 11 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-10-12 Completed Date: 2001-12-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 185-90 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Graduate Program in Genes & Development, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA. nfossett@odin.mdacc.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Conserved Sequence DNA-Binding Proteins / physiology* Drosophila / embryology, genetics Drosophila Proteins* Gene Expression Regulation, Developmental / physiology* Heart / embryology* Receptors, Fibroblast Growth Factor / physiology Signal Transduction Transcription Factors / physiology* Zinc Fingers / physiology* |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Receptors, Fibroblast Growth Factor; 0/Transcription Factors; 0/u-shaped protein, Drosophila |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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