| The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. | |
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MedLine Citation:
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PMID: 19081077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. Here we show that SZY-20, a putative RNA-binding protein, plays a critical role in limiting centrosome size in C. elegans. SZY-20 localizes in part to centrosomes and in its absence centrosomes possess increased levels of centriolar and pericentriolar components including gamma-tubulin and the centriole duplication factors ZYG-1 and SPD-2. These enlarged centrosomes possess normal centrioles, nucleate more microtubules, and fail to properly direct a number of microtubule-dependent processes. Depletion of ZYG-1 restores normal centrosome size and function to szy-20 mutants, whereas loss of szy-20 suppresses the centrosome duplication defects in both zyg-1 and spd-2 mutants. Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process. |
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Authors:
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Mi Hye Song; L Aravind; Thomas Müller-Reichert; Kevin F O'Connell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Developmental cell Volume: 15 ISSN: 1878-1551 ISO Abbreviation: Dev. Cell Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-01-15 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 901-12 Citation Subset: IM |
Affiliation:
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Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20894, USA. mihyesong@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / chemistry, metabolism, physiology* Cell Nucleus / metabolism Centrioles / ultrastructure Centrosome / ultrastructure* Gene Expression Regulation, Developmental* Microtubules / metabolism Models, Biological Models, Genetic Mutation Protein Kinases / chemistry, metabolism, physiology* Protein-Serine-Threonine Kinases / metabolism* RNA-Binding Proteins / metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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ZIA DK024151-07/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/RNA-Binding Proteins; 0/SZY-20 protein, C elegans; EC 2.7.-/Protein Kinases; EC 2.7.1.-/zyg-1 protein, C elegans; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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