| Conservative treatment for patients with intermittent claudication. | |
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MedLine Citation:
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PMID: 20357750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The effect of pharmacotherapy or supervised exercise training on patients with intermittent claudication was assessed. METHODS: One hundred patients with stable intermittent claudication due to arteriosclerosis obliterans were analyzed. We divided the patients into 2 groups: patients treated by pharmacotherapy alone (Group A: 39 claudicants) and patients treated by supervised exercise training and pharmacotherapy (Group B: 61 claudicants). The changes in ankle-brachial pressure index (ABI) and recovery time of ABI after a 40-m walk (RT(40)) and absolute claudication distance (ACD) on a treadmill before and after each treatment were assessed. RESULTS: In Group A, RT(40) decreased from 9.5 +/- 5.8 min at the baseline to 6.4 +/- 3.5 min after 6 months (P=0.0002). In Group B, it decreased from 9.7+/-5.2 min at the baseline to 6.3+/-4.2 min after 3 weeks (P<0.0001). In Group A, ACD increased from 249+/-177 m at the baseline to 317+/-168 m after 6 months (P=0.0003). In Group B, it increased from 143+/-90 m at the baseline to 257+/-161 m after 3 weeks (P<0.0001). CONCLUSION: Hemodynamics and walking ability were improved by either short-term supervised exercise training or midterm pharmacotherapy. RT(40) may be useful for predicting the effect of conservative treatment on intermittent claudication. Greater increases in ACD after treatment can be achieved in claudicants with a shorter RT(40) before conservative treatment. |
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Authors:
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I Sugimoto; T Ohta; H Ishibashi; H Iwata; T Yamada; M Tadakoshi; N Hida; Y Orimoto |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International angiology : a journal of the International Union of Angiology Volume: 29 ISSN: 1827-1839 ISO Abbreviation: Int Angiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402693 Medline TA: Int Angiol Country: Italy |
Other Details:
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Languages: eng Pagination: 55-60 Citation Subset: IM |
Affiliation:
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Department of Vascular Surgery, Aichi Medical University, Nagakute-cho, Aichi, Japan. takum@surg2.med.kyushu-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Ankle Brachial Index Arteriosclerosis Obliterans / complications, drug therapy, physiopathology, therapy* Blood Pressure / drug effects Cardiovascular Agents / therapeutic use* Combined Modality Therapy Exercise Test Exercise Therapy* Exercise Tolerance / drug effects Female Humans Intermittent Claudication / drug therapy, etiology, physiopathology, therapy* Male Middle Aged Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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