Document Detail

Conservative treatment for patients with intermittent claudication.
MedLine Citation:
PMID:  20357750     Owner:  NLM     Status:  MEDLINE    
AIM: The effect of pharmacotherapy or supervised exercise training on patients with intermittent claudication was assessed. METHODS: One hundred patients with stable intermittent claudication due to arteriosclerosis obliterans were analyzed. We divided the patients into 2 groups: patients treated by pharmacotherapy alone (Group A: 39 claudicants) and patients treated by supervised exercise training and pharmacotherapy (Group B: 61 claudicants). The changes in ankle-brachial pressure index (ABI) and recovery time of ABI after a 40-m walk (RT(40)) and absolute claudication distance (ACD) on a treadmill before and after each treatment were assessed. RESULTS: In Group A, RT(40) decreased from 9.5 +/- 5.8 min at the baseline to 6.4 +/- 3.5 min after 6 months (P=0.0002). In Group B, it decreased from 9.7+/-5.2 min at the baseline to 6.3+/-4.2 min after 3 weeks (P<0.0001). In Group A, ACD increased from 249+/-177 m at the baseline to 317+/-168 m after 6 months (P=0.0003). In Group B, it increased from 143+/-90 m at the baseline to 257+/-161 m after 3 weeks (P<0.0001). CONCLUSION: Hemodynamics and walking ability were improved by either short-term supervised exercise training or midterm pharmacotherapy. RT(40) may be useful for predicting the effect of conservative treatment on intermittent claudication. Greater increases in ACD after treatment can be achieved in claudicants with a shorter RT(40) before conservative treatment.
I Sugimoto; T Ohta; H Ishibashi; H Iwata; T Yamada; M Tadakoshi; N Hida; Y Orimoto
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  29     ISSN:  1827-1839     ISO Abbreviation:  Int Angiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-01     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Department of Vascular Surgery, Aichi Medical University, Nagakute-cho, Aichi, Japan.
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MeSH Terms
Aged, 80 and over
Ankle Brachial Index
Arteriosclerosis Obliterans / complications,  drug therapy,  physiopathology,  therapy*
Blood Pressure / drug effects
Cardiovascular Agents / therapeutic use*
Combined Modality Therapy
Exercise Test
Exercise Therapy*
Exercise Tolerance / drug effects
Intermittent Claudication / drug therapy,  etiology,  physiopathology,  therapy*
Middle Aged
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Cardiovascular Agents

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