Document Detail

Conservative treatment of external pancreatic fistulas with parenteral nutrition alone or in combination with continuous intravenous infusion of somatostatin, glucagon or calcitonin.
MedLine Citation:
PMID:  2877505     Owner:  NLM     Status:  MEDLINE    
Treatment with total parenteral nutrition (TPN) alone or combined with continuous intravenous infusion of either somatostatin or calcitonin or glucagon have been carried out upon 45 patients with a high output external pancreatic fistula. No significant difference among these treatment schedules was observed in the percentage of closure of fistulas (85 to 100 per cent of the patients), but patients treated with TPN plus somatostatin had the fistulas close within a significantly (p = 0.000028) shorter period of time. Moreover, this treatment was associated with the strongest inhibition of the output from the fistula (minus 82.3 per cent). Since treatment with somatostatin was not accompanied by any side effect, was followed by a quite rapid closure of the fistulas and allowed an estimated economic savings of about $2,100.00 dollars per patient, it seems to be advisable in the conservative treatment of external pancreatic fistulas.
P Pederzoli; C Bassi; M Falconi; R Albrigo; I Vantini; R Micciolo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  163     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-02     Completed Date:  1986-12-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  428-32     Citation Subset:  AIM; IM    
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MeSH Terms
Calcitonin / therapeutic use*
Glucagon / therapeutic use*
Infusions, Intravenous
Pancreatic Fistula / physiopathology,  therapy*
Parenteral Nutrition, Total*
Somatostatin / therapeutic use*
Time Factors
Reg. No./Substance:
51110-01-1/Somatostatin; 9007-12-9/Calcitonin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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