Document Detail

Conservative surgery and radiation therapy for invasive lobular carcinoma of the breast.
MedLine Citation:
PMID:  10392891     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is debate as to whether infiltrating lobular carcinoma (ILC) can be effectively treated with breast conservative surgery (CS) and radiotherapy (RT) because of a perceived high risk of local recurrence. This retrospective study examined the outcome of patients with ILC treated by CS and RT. METHODS: Between November 1979 and December 1994, 57 women with UICC Stage I or II ILC were treated by CS and RT at Westmead Hospital, New South Wales, Australia. The median age was 55 years (range 28-79). Twelve patients (21%) underwent a re-excision after initial CS. The final margins were clear for 43 patients (75.4%), positive (invasive or in situ) for nine patients (15.8%), and indeterminate for five patients (8.8%). All patients received whole-breast irradiation (45-50.4 Gy) usually supplemented by a boost (10-30 Gy). Fifty-three of 57 patients (93%) had their pathology reviewed at Westmead Hospital. RESULTS: After a median follow up of 69 months (range 36-162) three patients (5.3%) developed a local recurrence. One of 43 patients (2.3%) with known clear margins developed a local recurrence compared with two of 14 patients (14.3%) with positive or indeterminate margins (P = NS). The 5- and 10-year rates of freedom from local recurrence were 96 and 93%, respectively. The 5-year disease-free survival was 85% (node-negative, 92%; node-positive, 66%). Overall survival was 94% at 5 years. No patient developed a contralateral breast cancer. CONCLUSION: Patients with ILC can be effectively treated with CS and RT.
M Francis; B Cakir; M Bilous; O Ung; J Boyages
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian and New Zealand journal of surgery     Volume:  69     ISSN:  0004-8682     ISO Abbreviation:  Aust N Z J Surg     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373115     Medline TA:  Aust N Z J Surg     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  450-4     Citation Subset:  IM    
Division of Radiation Oncology, Westmead Hospital, and NSW Breast Cancer Institute, University of Sydney, New South Wales, Australia.
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MeSH Terms
Actuarial Analysis
Breast Neoplasms / radiotherapy*,  surgery*
Carcinoma, Ductal, Breast / radiotherapy*,  surgery*
Carcinoma, Lobular / radiotherapy*,  surgery*
Combined Modality Therapy
Disease-Free Survival
Follow-Up Studies
Middle Aged
Neoplasm Recurrence, Local / epidemiology
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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