Document Detail


Conservative surgery plus adjuvant therapy for vulvovaginal rhabdomyosarcoma, diethylstilbestrol clear cell adenocarcinoma of the vagina, and unilateral germ cell tumors of the ovary.
MedLine Citation:
PMID:  1316595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant progress has been made in the 1980s in early-stage vulvovaginal rhabdomyosarcoma, diethylstilbestrol (DES) clear cell adenocarcinoma of the vagina, and unilateral germ cell tumors of the ovary. In an early state of vulvovaginal rhabdomyosarcoma, systemic vincristine, dactinomycin, and cyclophosphamide (VAC) chemotherapy followed by local excision or local radiation results in a high cure rate with retention of future fertility. Similarly, early-stage DES-related adenocarcinoma of the vagina treated by wide local excision and localized vaginal radiation also results in retention of fertility and a high cure rate. Finally, significant progress has been made in unilateral germ cell tumors of the ovary in which surgical treatment by unilateral salpingo-oophorectomy followed by cisplatin, etoposide, and bleomycin results in not only high cure rates and retention of fertility but will probably be standard therapy for all germ cell tumors of the ovary, including dysgerminoma, a disease most frequently treated in the past by radiation therapy with loss of subsequent fertility.
Authors:
M L Hicks; M S Piver
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology clinics of North America     Volume:  19     ISSN:  0889-8545     ISO Abbreviation:  Obstet. Gynecol. Clin. North Am.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-18     Completed Date:  1992-06-18     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8709551     Medline TA:  Obstet Gynecol Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-33     Citation Subset:  IM    
Affiliation:
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy,  surgery*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chemotherapy, Adjuvant
Child
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Dactinomycin / administration & dosage
Female
Humans
Neoplasms, Germ Cell and Embryonal / drug therapy,  surgery*
Ovarian Neoplasms / drug therapy,  surgery*
Rhabdomyosarcoma / drug therapy,  surgery*
Vaginal Neoplasms / drug therapy,  surgery*
Vincristine / administration & dosage
Vulvar Neoplasms / drug therapy,  surgery*
Chemical
Reg. No./Substance:
0/VAC protocol; 50-18-0/Cyclophosphamide; 50-76-0/Dactinomycin; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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