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Conservative management of young women with endometrial carcinoma or complex atypical hyperplasia: report of three cases and literature review.
MedLine Citation:
PMID:  22335041     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Although endometrial cancer is primarily a postmenopausal disease, 25% of patients are in premenopausal age with 3-5% being 40 years old or younger. The younger groups of women with endometrial carcinoma are frequently nulligravid with a history of infertility and strong desire to preserve fertility, which may pose a therapeutic dilemma for both patients and physicians.
CASE REPORTS: We report on three young women with atypical complex hyperplasia or early-stage endometrial cancer that were treated with conservative hormonal therapy.
DISCUSSION/CONCLUSION: Hormonal therapy has been proposed for young women with endometrial cancer (grade 1) who wish to preserve their fertility. However, detailed evaluation including physical examination, history taking, performing D&C, examining the specimen by a skilled pathologist, using imaging techniques, especially contrast enhanced MRI and for some patients explorative laparoscopy with sampling of peritoneal and lymph nodes, and evaluation of adnexa is necessary. Also for patients in Stage I/grade 1, advisory sessions on the benefits and side-effects of high-dose progesterone with evaluation of the endometrium every three months until total regression is recommended.
Authors:
M Karimi-Zarchi; A S Mousavi; N Behtash; Z Chiti; M Bokaie
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  32     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  695-8     Citation Subset:  IM    
Affiliation:
Gynecology-Oncology Department, Shahid Sadoughi University of Medical Science, Yazd, Iran. drkarimi2001@yahoo.com
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