Document Detail


Conservative management of extra-adrenal pheochromocytoma during pregnancy.
MedLine Citation:
PMID:  15863575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Extra-adrenal pheochromocytomas are catecholamine-secreting tumors that arise from chromaffin cells of the paraganglion sympathetic system. All of the previously reported cases have described surgical resection during the antepartum period. CASE: At 14 weeks of gestation, a multiparous patient was diagnosed with an extra-adrenal dopaminergic pheochromocytoma. A decision was made to delay surgical intervention until the postpartum period. Phenoxybenzamine, 10 mg per day, was subsequently started. At 35 + 2 weeks of gestation, the patient delivered a 2,600 g infant via an uncomplicated cesarean. Three weeks later, the extra-adrenal pheochromocytoma was removed, and she also underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and rectosigmoid resection with end-to-end colostomy. CONCLUSION: Conservative management of dopaminergic-secreting extra-adrenal pheochromocytomas can result in favorable maternal and fetal outcomes.
Authors:
Caela Miller; Victor Bernet; John C Elkas; Louis Dainty; Robert B Gherman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  105     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-30     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1185-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Division of Maternal/Fetal Medicine, National Naval Medical Center, Bethesda, Maryland 20889, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / diagnosis,  drug therapy*
Adrenalectomy / methods
Adult
Biopsy, Needle
Cesarean Section
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Gestational Age
Humans
Immunohistochemistry
Phenoxybenzamine / therapeutic use*
Pheochromocytoma / diagnosis,  drug therapy*
Postpartum Period
Pregnancy
Pregnancy Complications, Neoplastic / diagnosis,  drug therapy*
Pregnancy Outcome*
Risk Assessment
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography, Prenatal
Chemical
Reg. No./Substance:
59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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