Document Detail


Conservation within artiodactyls of an AATA interrupt in the IGF-I microsatellite for 19-35 million years.
MedLine Citation:
PMID:  10742057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Occurrence of an AATA interrupt in the IGF-I microsatellite was investigated in a number of Artiodactyl species, namely pigs, camels, deer, cattle, goats, and sheep. Comparison of DNA sequences in the 5' flank of the microsatellite in these species revealed that the interrupt within the microsatellite is conserved in deer, cattle, sheep, and goats but is absent from camels and pigs. The interrupt was introduced into the Artiodactyl phylogeny after the divergence of the Camelidae but before the divergence of the Cervidae, and thus its time of origin can be estimated to be 19-35 MYA. In contrast to the repeat units which are hypermutable, the interrupt has been conserved for a very long time and may even have suppressed microsatellite variation by inhibiting replication slippage. A 12-bp deletion in the 5' flank of the microsatellite in camels corresponds to a consensus reversed repeat in deer, cattle, sheep, and goats with unknown functional significance. Apart from this deletion, the 5' flank of the microsatellite is highly conserved in Artiodactyl species.
Authors:
M Reza Shariflou; C Moran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular biology and evolution     Volume:  17     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-15     Completed Date:  2000-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-9     Citation Subset:  IM    
Affiliation:
Department of Animal Sciences, University of Sydney, New South Wales, Australia. msharifli@pop.usyd.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Artiodactyla / genetics*
Base Sequence
Cattle
Conserved Sequence / genetics*
Evolution, Molecular
Humans
Insulin-Like Growth Factor I / genetics*
Microsatellite Repeats / genetics*
Molecular Sequence Data
Phylogeny
Rats
Sequence Alignment
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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