| Conservation within artiodactyls of an AATA interrupt in the IGF-I microsatellite for 19-35 million years. | |
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MedLine Citation:
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PMID: 10742057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occurrence of an AATA interrupt in the IGF-I microsatellite was investigated in a number of Artiodactyl species, namely pigs, camels, deer, cattle, goats, and sheep. Comparison of DNA sequences in the 5' flank of the microsatellite in these species revealed that the interrupt within the microsatellite is conserved in deer, cattle, sheep, and goats but is absent from camels and pigs. The interrupt was introduced into the Artiodactyl phylogeny after the divergence of the Camelidae but before the divergence of the Cervidae, and thus its time of origin can be estimated to be 19-35 MYA. In contrast to the repeat units which are hypermutable, the interrupt has been conserved for a very long time and may even have suppressed microsatellite variation by inhibiting replication slippage. A 12-bp deletion in the 5' flank of the microsatellite in camels corresponds to a consensus reversed repeat in deer, cattle, sheep, and goats with unknown functional significance. Apart from this deletion, the 5' flank of the microsatellite is highly conserved in Artiodactyl species. |
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Authors:
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M Reza Shariflou; C Moran |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular biology and evolution Volume: 17 ISSN: 0737-4038 ISO Abbreviation: Mol. Biol. Evol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-15 Completed Date: 2000-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501455 Medline TA: Mol Biol Evol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 665-9 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, University of Sydney, New South Wales, Australia. msharifli@pop.usyd.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Artiodactyla / genetics* Base Sequence Cattle Conserved Sequence / genetics* Evolution, Molecular Humans Insulin-Like Growth Factor I / genetics* Microsatellite Repeats / genetics* Molecular Sequence Data Phylogeny Rats Sequence Alignment Sequence Analysis, DNA |
| Chemical | |
Reg. No./Substance:
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67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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