Document Detail


Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
MedLine Citation:
PMID:  18818364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.
Authors:
Assen Roguev; Sourav Bandyopadhyay; Martin Zofall; Ke Zhang; Tamas Fischer; Sean R Collins; Hongjing Qu; Michael Shales; Han-Oh Park; Jacqueline Hayles; Kwang-Lae Hoe; Dong-Uk Kim; Trey Ideker; Shiv I Grewal; Jonathan S Weissman; Nevan J Krogan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-09-25
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  322     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-17     Completed Date:  2008-11-03     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
DNA Repair
DNA Replication
Epistasis, Genetic*
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Genes, Fungal*
Histones / metabolism
Mutation
RNA Interference
Saccharomyces cerevisiae / genetics,  metabolism
Schizosaccharomyces / genetics*,  metabolism
Schizosaccharomyces pombe Proteins / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
GM084279/GM/NIGMS NIH HHS; R01 GM084279/GM/NIGMS NIH HHS; R01 GM084279-01A1/GM/NIGMS NIH HHS; R01 GM084279-02/GM/NIGMS NIH HHS; R01 GM084279-02S1/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Histones; 0/Schizosaccharomyces pombe Proteins
Comments/Corrections

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