Document Detail

Conservation of the paired domain in metazoans and its structure in three isolated human genes.
MedLine Citation:
PMID:  2501086     Owner:  NLM     Status:  MEDLINE    
Sequences homologous to the paired domain of Drosophila melanogaster have been conserved in species as distantly related as nematodes, sea urchins, or man. In particular, paired domains of three human genes, HuP1, HuP2 and HuP48, have been isolated and sequenced. Together with four Drosophila paired domains, they fall into two separate paired domain classes named according to their Drosophila members, paired--gooseberry and P29 class. The P29 class includes the mouse Pax 1 and the human HuP48 gene which are nearly identical in their sequenced portions and hence might be true homologues. In addition to the paired domain, the two human genes HuP1 and HuP2 share the highly conserved octapeptide HSIAGILG with the two gooseberry genes of Drosophila. Possible functions of the paired domain are discussed in the light of a predicted helix-turn-helix structure in its carboxy-terminal portion.
M Burri; Y Tromvoukis; D Bopp; G Frigerio; M Noll
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The EMBO journal     Volume:  8     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-16     Completed Date:  1989-08-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1183-90     Citation Subset:  IM    
Department of Cell Biology, Biocenter of the University, Basel, Switzerland.
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MeSH Terms
Amino Acid Sequence
Base Sequence*
DNA / genetics
Drosophila melanogaster / genetics
Molecular Sequence Data
Restriction Mapping
Sequence Homology, Nucleic Acid*
Species Specificity
Reg. No./Substance:

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