Document Detail

Conservation of gene order in human microRNA-neighboring regions.
MedLine Citation:
PMID:  22950798     Owner:  NLM     Status:  Publisher    
The biological function and evolution of microRNAs (miRNAs), an important class of noncoding regulatory genes, have attracted wide interest. However, their evolutionary impact on gene order rearrangements remains unknown. We examined the gene-order stability of miRNA-neighboring regions by a comparative human-mouse genomic analysis and found that the neighboring genes of human miRNAs tend to have a conserved gene order. This observation cannot be attributed to the functional bias of neighboring genes, and is a unique characteristic of miRNAs but not other noncoding RNAs. Our findings suggest that mammalian miRNAs stabilize the genomic architecture in evolution.
Jianshu Chen; Wei Chen; Yudong Li
Related Documents :
17008408 - Phosphodiesterase genes are associated with susceptibility to major depression and anti...
23424248 - A role for max1 in evolutionary diversity in strigolactone signalling upstream of max2.
25134718 - Analysis of high fat diet induced genes during mammary gland development: identifying r...
23720678 - Prognostic value of met, cyclin d1 and met gene copy number in non-small cell lung cancer.
2908178 - Clonotypic analysis of the fetal b cell repertoire: evidence for an early and predomina...
23583758 - Systematic screening of a drosophila orf library in vivo uncovers wnt/wg pathway compo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-5
Journal Detail:
Title:  Genome / National Research Council Canada = Genome / Conseil national de recherches Canada     Volume:  -     ISSN:  1480-3321     ISO Abbreviation:  Genome     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704544     Medline TA:  Genome     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Department of Biological Engineering, Zhejiang Gongshang University, Hangzhou 310035, P.R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of a 65 kDa NIF in the nuclear matrix of the monocot Allium cepa that interacts wit...
Next Document:  The prebiotic effect of Anoectochilus formosanus and its consequences on bone health.