Document Detail


Conservation of gene order in human microRNA-neighboring regions.
MedLine Citation:
PMID:  22950798     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The biological function and evolution of microRNAs (miRNAs), an important class of noncoding regulatory genes, have attracted wide interest. However, their evolutionary impact on gene order rearrangements remains unknown. We examined the gene-order stability of miRNA-neighboring regions by a comparative human-mouse genomic analysis and found that the neighboring genes of human miRNAs tend to have a conserved gene order. This observation cannot be attributed to the functional bias of neighboring genes, and is a unique characteristic of miRNAs but not other noncoding RNAs. Our findings suggest that mammalian miRNAs stabilize the genomic architecture in evolution.
Authors:
Jianshu Chen; Wei Chen; Yudong Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-5
Journal Detail:
Title:  Genome / National Research Council Canada = Genome / Conseil national de recherches Canada     Volume:  -     ISSN:  1480-3321     ISO Abbreviation:  Genome     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704544     Medline TA:  Genome     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Department of Biological Engineering, Zhejiang Gongshang University, Hangzhou 310035, P.R. China.
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