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Conservation and characterization of unique porcine interstitial telomeric sequences.
MedLine Citation:
PMID:  23233217     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Telomeres are composed of TTAGGG repeats and located at the ends of chromosomes. Telomeres protect chromosomes from instability in mammals, including mice and humans. Repetitive TTAGGG sequences are also found at intrachromosomal sites, where they are named as interstitial telomeric sequences (ITSs). Aberrant ITSs are implicated in chromosomal instability and found in cancer cells. Interestingly, in pigs, vertebrate telomere sequences TTAGGG (vITSs) are also localized at the centromeric region of chromosome 6, in addition to the end of all chromosomes. Surprisingly, we found that botanic telomere sequences, TTTAGGG (bITSs), also localize with vITSs at the centromeric regions of pig chromosome 6 using telomere fluorescence in situ hybridization (FISH) and by comparisons between several species. Furthermore, the average lengths of vITSs are highly correlated with those of the terminal telomeres (TTS). Also, pig ITSs show a high incidence of telomere doublets, suggesting that pig ITSs might be unstable and dynamic. Together, our results show that pig cells maintain the conserved telomere sequences that are found at the ITSs from of plants and other vertebrates. Further understanding of the function and regulation of pig ITSs may provide new clues for evolution and chromosomal instability.
Authors:
Guangzhen Ji; Kai Liu; Chengbin Chen; Weimin Ruan; Christina Glytsou; Yang Yang; Maja Okuka; Wenqing Song; Sarantis Gagos; Ning Li; Lin Liu
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Publication Detail:
Type:  Journal Article     Date:  2012-12-12
Journal Detail:
Title:  Science China. Life sciences     Volume:  55     ISSN:  1869-1889     ISO Abbreviation:  Sci China Life Sci     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101529880     Medline TA:  Sci China Life Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  1029-37     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
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