Document Detail

Consequences of telomere shortening during lifespan.
MedLine Citation:
PMID:  23127607     Owner:  NLM     Status:  Publisher    
Telomerase expression is restricted in human cells and so telomeres shorten throughout our lives, providing a tumour suppressor mechanism that limits cell proliferation. As a trade-off, continuous telomere erosion results in replicative senescence and contributes to ageing. Recently, telomerase therapies were proposed as a valid approach to rescue degenerative phenotypes caused by telomere dysfunction. However, systemic effects initiated by short telomeres may prove dominant in limiting tissue renewal in the whole organism. Most of our knowledge of telomere biology derives from mouse models that do not rely on telomere exhaustion for controlling cell proliferation and tissue homeostasis. In order to understand the impact of telomere shortening in natural ageing, we need to investigate animal models that, like humans, have evolved to have telomere length as a cell division clock.
Catarina M Henriques; Miguel Godinho Ferreira
Related Documents :
23528127 - Potential mechanisms for the effects of tea extracts on the attachment, biofilm formati...
23932127 - Toward directed reprogramming through exogenous factors.
24325797 - Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early...
23646617 - Comparative bio-effects of sio2/gd2o3 nanoparticles depending on their core-shell struc...
22910297 - Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free m...
23528127 - Potential mechanisms for the effects of tea extracts on the attachment, biofilm formati...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-2
Journal Detail:
Title:  Current opinion in cell biology     Volume:  -     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ultrastructure and Molecular Phylogeny of the Cryptomonad Goniomonas avonlea sp. nov.
Next Document:  Cadherin junctions and their cytoskeleton(s).