Document Detail


Consequences of renal mass reduction on amino acid and biogenic amine levels in nephrectomized mice.
MedLine Citation:
PMID:  10901623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amino acid and biogenic amine changes were investigated in nephrectomized mice ten days postsurgery. Uremic mice exhibited changes in amino acid concentrations in plasma, urine and brain. Particularly plasma methionine, citrulline and arginine levels were significantly enhanced in nephrectomized mice compared to controls whereas serine was decreased. Urinary excretion of methionine, citrulline and alanine was higher in nephrectomized mice compared to controls whereas many amino acids were increased in brain of nephrectomized mice. Brain and urinary amino acid changes were more pronounced in the 75% than in the 50% nephrectomized mice. Brain norepinephrine and dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly increased whereas serotonin was decreased comparing the 75% nephrectomized mice to the sham-operated mice. This study demonstrates that at very early stages of renal insufficiency, specific amino acid and biogenic amine changes occur in plasma, urine and brain. These alterations might depend qualitatively and quantitatively on the degree of functional renal mass reduction.
Authors:
M Al Banchaabouchi; B Marescau; R D'Hooge; S Engelborghs; P P De Deyn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Amino acids     Volume:  18     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2000  
Date Detail:
Created Date:  2000-10-16     Completed Date:  2001-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  265-77     Citation Subset:  IM    
Affiliation:
Department of Neurology, Born-Bunge Foundation, University of Antwerp, Belgium.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Alanine / urine
Amino Acids / blood,  metabolism*,  urine
Animals
Biogenic Amines / metabolism*
Brain / metabolism
Citrulline / blood,  urine
Dopamine / metabolism
Homovanillic Acid / metabolism
Kidney / metabolism*,  surgery*
Kidney Failure / metabolism*
Male
Methionine / blood,  urine
Mice
Mice, Inbred C57BL
Nephrectomy
Norepinephrine / metabolism
Serotonin / metabolism
Uremia / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Amines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 372-75-8/Citrulline; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 56-41-7/Alanine; 63-68-3/Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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