| Consequences of progestational hypoxia in pregnant rats and its peptide correction (EEG data). | |
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MedLine Citation:
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PMID: 12937663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied immediate and delayed changes in ECG in female albino rats subjected to acute hypobaric hypoxia on days 4-5 of pregnancy and evaluated the possibility of correction of hypoxia-produced disturbances with some peptides. Acute hypoxia lengthened the mean RR interval, increased heart rate variability, and decreased the monotony index. Hypoxia induced considerable changes in the structure of ECG that reflected the development of arrhythmias and conduction disturbances. These changes in ECG persisted during the posthypoxic period. Intranasal administration of heptapeptides Semax and beta-casomorphin-7 to pregnant females promoted recovery from acute hypoxia and normalized ECG in the posthypoxic period. |
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Authors:
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M V Maslova; A V Graf; N S Samoilenkova; A S Maklakova; N A Sokolova; L A Andreeva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 135 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-08-25 Completed Date: 2004-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 526-9 Citation Subset: IM |
Affiliation:
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Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. maslova_mash@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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analogs & derivatives*,
metabolism* Animals Anoxia / metabolism* Atmospheric Pressure Electrocardiography* Endorphins / metabolism* Female Heart Rate / physiology Myocardium / metabolism Peptide Fragments / metabolism* Pregnancy Rats |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 0/Peptide Fragments; 72122-62-4/beta-casomorphin 7; 80714-61-0/ACTH (4-7), Pro-Gly-Pro-; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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