Document Detail


Consequences of not treating children with laron syndrome (primary growth hormone insensitivity).
MedLine Citation:
PMID:  11964019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The follow-up of a large cohort of patients with Laron syndrome (LS) from infancy to adult age has enabled us to determine the effects of long-term insulin-like growth factor-I (IGF-I) deficiency on auxological, biochemical, physiological and psychological parameters. We found that early and continuous IGF-I deficiency (the anabolic effector of growth hormone) causes dwarfism, acromicria, organomicria, marked obesity, insulin resistance, retardation of skeletal maturation and osteoporosis, as well as muscular and central nervous tissue underdevelopment, and a series of biochemical changes including hypercholesterolemia. These multiple pathologies impair the quality of life of these patients. It is concluded that patients with LS need IGF-I replacement treatment throughout life.
Authors:
Z Laron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  14 Suppl 5     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2001  
Date Detail:
Created Date:  2002-04-19     Completed Date:  2002-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1243-8; discussion 1261-2     Citation Subset:  IM    
Affiliation:
Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Tel Aviv University, Israel. laronz@clalit.org.il
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Growth Disorders / etiology*,  pathology,  physiopathology,  psychology,  therapy
Human Growth Hormone / physiology*
Humans
Insulin-Like Growth Factor I / deficiency,  therapeutic use
Male
Syndrome
Chemical
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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