Document Detail

Consequences of endocrine disrupting chemicals on reproductive endocrine function in birds: establishing reliable end points of exposure.
MedLine Citation:
PMID:  15998506     Owner:  NLM     Status:  MEDLINE    
It has been difficult to establish reliable indices of exposure to endocrine disrupting chemicals (EDCs) appropriate for a variety of avian species because of a vast array of reproductive strategies. Data from mammals, reptiles and fish provide insight on likely mechanisms of action for EDCs. However, many of the effects of EDCs are weaker than the actions of the native hormones, making it difficult to assess adverse effects in domestic and wild birds. It is clear that differential sensitivity to EDCs exists across species, due to the timing and mode of exposure, compound toxicity and age of the individual. Our studies on EDCs are conducted in the quail model system, with focus on reproductive endocrine, neuroendocrine and behavioral responses. Studies have included EDC exposure, either by egg injection or via diet. Results from egg injection studies showed the following: (1) estradiol administered by embryonic day 12 demasculinized male sexual behavior, altered hypothalamic neurotransmitters and reduced hen day production and fertility in a dose dependent fashion, (2) methoxychlor (MXC) or vinclozolin impaired male sexual behavior in adult quail and (3) DDE exposure impaired reproductive and immune related end points. Two-generation studies were conducted on Japanese and northern bobwhite quail with dietary methoxychlor (MXC) exposure (0, 5 and 10 ppm) beginning in adults (P1), continuing in their offspring (F1), with F2 offspring raised on control diet. MXC exposure impaired male sexual behavior, hypothalamic catecholamines and plasma steroid hormones. Moreover, MXC exposure had reproductive consequences observable at both the lower and higher doses of MXC in F1 and F2 generations. These data demonstrate that embryonic EDC exposure interferes with sexual differentiation of neural systems that direct reproduction.
M A Ottinger; M J Quinn; E Lavoie; M A Abdelnabi; N Thompson; J L Hazelton; J M Wu; J Beavers; M Jaber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2005-04-07
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  29     ISSN:  0739-7240     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-06     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-9     Citation Subset:  IM    
Department of Animal and Avian Sciences, University of Maryland, 3115 Animal Sciences Building, College Park, MD 20742, USA.
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MeSH Terms
Androgens / toxicity*
Birds / physiology*
Coturnix / physiology
Dichlorodiphenyl Dichloroethylene / toxicity
Embryo, Nonmammalian / drug effects
Endocrine Glands / drug effects*
Environmental Exposure*
Estrogens / toxicity*
Insecticides / toxicity
Methoxychlor / toxicity
Reproduction / drug effects*
Reg. No./Substance:
0/Androgens; 0/Estrogens; 0/Insecticides; 72-43-5/Methoxychlor; 72-55-9/Dichlorodiphenyl Dichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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