Document Detail


Consequences of early life MK-801 administration: Long-term behavioural effects and relevance to schizophrenia research.
MedLine Citation:
PMID:  22085878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Animal models contribute significantly to advancing the understanding of schizophrenia neurobiology, in addition to being an important tool for the screening of antipsychotic potential of new compounds. However, the entire spectrum or all the symptoms manifested in schizophrenia cannot be straightforwardly reproduced in animals due to the complexity of the disorder, difference in mental capacities and behaviours, and the ability to quantify or measure the changes. Blockade of the NMDA receptor by the use of MK-801, a non-competitive NMDA receptor antagonist, during the early postnatal period has been proposed to be an experimental model which induces behavioural changes that mimic several aspects of the disorder. The long term behavioural profile arising from this early life manipulation is reviewed herein, with a specific focus on behaviours relevant to a schizophrenia-like condition. Some of the reported neurochemical changes are also compiled. Although this method may be suitable to model some aspects of schizophrenia in rodents, there are unmet areas which need to be addressed, notably the characterisation of its predictive value.
Authors:
Ann Li Lim; David Alan Taylor; Daniel Thomas Malone
Related Documents :
21694868 - Treating acid reflux disease in patients with down syndrome: pharmacological and physio...
11262988 - Burden of genetic disorders in india.
10654118 - Validating the ontario child health scale in a uk population.
7737788 - Catatonia on the consultation-liaison service: a replication study.
15881268 - 'the ghost pushes you down': sleep paralysis-type panic attacks in a khmer refugee popu...
10546978 - Childhood-onset schizophrenia: a follow-up study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-9
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both co...
Next Document:  Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in ...