| Consequences of adrenalectomy on small intestine trophic parameters in aged and young rats: evidence of defective adaptation by aging and lack of corticoids. | |
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MedLine Citation:
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PMID: 12822878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous study pointed to an important role of adrenals and glucocorticoids in the trophic status of the adult small intestine mucosa, with possible implications during stress events. Small intestine morphological and biochemical consequences of 10-day bilateral adrenalectomy and also sham-related laparotomy were determined in 23-month-old Sprague-Dawley rats. As described in young rats, adrenalectomy in old rats leads to partial atrophy and disorganization of the proximal small intestine epithelium, with an increase in the number of Paneth cells and reduced crypt cell proliferation. We also observed a decrease of goblet cell number and a reduction of all enzyme activities including disaccharidases, in contrast with the specific induced response shown in young rats. A number of marked biochemical effects have also been noted in aged rats subjected to solely laparotomy, suggesting age-related adaptation impairments. In conclusion, adrenalectomy modified the differentiation processes of the small intestinal mucosa in both young and aged rats, and some parameters underlined that the lack of corticoid-mediated adaptive process are exacerbated by cumulative surgical stress (event) and aging. |
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Authors:
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Benoit Foligne; Francoise Senegas-Balas; Raffaele Cursio; Chantal Cayuela; Jean-Michel Antoine; Nathalie Rolf-Petersen; Daniel Balas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 48 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-25 Completed Date: 2003-07-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1147-58 Citation Subset: AIM; IM |
Affiliation:
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Laboratoire d'Histologie, Faculté de Médecine, Université de Nice-Sophia Antipolis, 06107 Nice cedex 2, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Adrenalectomy* Aging / physiology* Animals Body Weight Cell Division Eating Glucocorticoids / physiology* Intestinal Mucosa / pathology Intestine, Small / growth & development*, physiopathology Male Rats Rats, Sprague-Dawley Stress, Physiological / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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